Purpose The purpose of this study was to examine posttraumatic growth (PTG), cancer coping, posttraumatic stress, and genetics knowledge among ovarian cancer survivors and to identify factors affecting PTG. Methods This cross-sectional study included 148 outpatient ovarian cancer survivors at a cancer center. Data were collected between February 25 and April 11, 2019, and were analyzed usingttests, ANOVA, Pearson-correlations, and multiple regression. Results On average, the ovarian cancer survivors scored 68.09 +/- 20.17 in PTG, 59.75 +/- 13.37 in cancer coping, 29.30 +/- 17.25 in posttraumatic stress, and 9.42 +/- 3.33 in genetics knowledge. There were significant differences in PTG according to religion (t= - 2.92,p= .004), marital status (F= 3.06,p= .050), and family history of cancer (t= 2.00,p= .047). In the final analysis, the statistically significant factors influencing PTG were religion (beta = .170,p= .004) and cancer coping (beta = .691,p< .001), and posttraumatic stress had borderline statistical significance (beta = - .107,p< .068). These factors explained 52.2% of the variance in PTG. Conclusions Ovarian cancer survivors showed a moderate level of genetics knowledge while having a high risk for posttraumatic stress. Overall, this study showed that cancer coping was a powerful factor that influenced PTG in ovarian cancer survivors. Religion was found to positively affect PTG, and posttraumatic stress had a small negative effect. Spiritual nursing interventions and improving cancer coping while reducing posttraumatic stress are necessary to increase the PTG of ovarian cancer survivors.