Efficient Synthesis of Chiral 2,2′-Bipyrrolidines by an anti-Selective Alkene Diamination

被引：21

作者：

Mueller, Christian H. ^{[1
]}

Froehlich, Roland ^{[1
]}

Daniliuc, Constantin G. ^{[1
]}

Hennecke, Ulrich ^{[1
]}

机构：

[1] Univ Munster, Inst Organ Chem, D-48149 Munster, Germany

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 23期

关键词：

PROMOTED INTRAMOLECULAR DIAMINATION; PALLADIUM-CATALYZED DIAMINATION; METAL-FREE DIAMINATION; OXIDATIVE DIAMINATION; CONJUGATED DIENES; REGIOSELECTIVE DIAMINATION; MECHANISTIC PATHWAYS; DIHYDROXYLATION; 1,2-DIAMINATION; SULFAMIDE;

D O I：

10.1021/ol302855z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The rapid and efficient construction of complex chiral bicyclic amines is possible using a novel alkene diamination reaction. Electrophilic iodinating agents promote the intramolecular anti-selective diamination of alkenes and allow the efficient synthesis of chiral amines such as trans-bipyrrolidines.

引用

页码：5944 / 5947

页数：4

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