Does transforming growth factor-β1 predict for radiation-induced pneumonitis in patients treated for lung cancer?

被引：36
|
作者：
Evans, Elizabeth S.
Kocak, Zafer
Zhou, Su-Min
Kahn, Daniel A.
Huang, Hong
Hollis, Donna R.
Light, Kim L.
Anscher, Mitchell S.
Marks, Lawrence B.
机构：
[1] Duke Univ, Med Ctr, Dept Radiat Oncol, Durham, NC 27710 USA
[2] Duke Univ, Med Ctr, Dept Biostat, Durham, NC 27710 USA
来源：
CYTOKINE | 2006年 / 35卷 / 3-4期
关键词：
TGF-beta; 1; radiation pneumonitis;
D O I：
10.1016/j.cyto.2006.07.021
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The purpose of the study was to reassess the utility of transforming growth factor-beta-1 (TGF-beta 1) together with dosimetric and tumor parameters as a predictor for radiation pneumonitis (RP). Of the 121 patients studied, 32 (26.4%) developed grade >= 1 RP, and 27 (22.3%) developed grade >= 2 RP. For the endpoint of grade >= 1 RP, those with V30 > 30% and an end-RT/baseline TGF-beta 1 ratio >= 1 had a significantly higher incidence of RP than did those with V30 > 30% and an end-RT/baseline TGF-beta 1 ratio < 1. For most other patient groups, there were no clear associations between TGF-beta 1 values and rates of RP. These findings suggest that TGF-beta 1 is generally not predictive for RP except for the group of patients with a high V30. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：186 / 192
页数：7
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