Population Bottlenecks and Intra-host Evolution During Human-to-Human Transmission of SARS-CoV-2

被引：18

作者：

Wang, Daxi ^{[1
,2
]}

Wang, Yanqun ^{[3
]}

Sun, Wanying ^{[1
,2
,4
]}

Zhang, Lu ^{[3
,5
]}

Ji, Jingkai ^{[1
,2
]}

Zhang, Zhaoyong ^{[3
]}

Cheng, Xinyi ^{[1
,2
,6
]}

Li, Yimin ^{[3
]}

Xiao, Fei ^{[7
]}

Zhu, Airu ^{[3
]}

Zhong, Bei ^{[8
]}

Ruan, Shicong ^{[9
]}

Li, Jiandong ^{[1
,2
,4
]}

Ren, Peidi ^{[1
,2
]}

Ou, Zhihua ^{[1
,2
]}

Xiao, Minfeng ^{[1
,2
]}

Li, Min ^{[1
,2
,4
]}

Deng, Ziqing ^{[1
,2
]}

Zhong, Huanzi ^{[1
,2
,10
]}

Li, Fuqiang ^{[1
,2
,11
]}

Wang, Wen-jing ^{[1
,11
]}

Zhang, Yongwei ^{[1
]}

Chen, Weijun ^{[4
,12
]}

Zhu, Shida ^{[1
,13
]}

Xu, Xun ^{[1
,14
]}

Jin, Xin ^{[1
]}

Zhao, Jingxian ^{[3
]}

Zhong, Nanshan ^{[3
]}

Zhang, Wenwei ^{[1
]}

Zhao, Jincun ^{[3
,5
]}

Li, Junhua ^{[1
,2
,6
]}

Xu, Yonghao ^{[3
]}

机构：

[1] BGI Shenzhen, Shenzhen, Peoples R China

[2] BGI Shenzhen, Shenzhen Key Lab Unknown Pathogen Identificat, Shenzhen, Peoples R China

[3] Guangzhou Med Univ, State Key Lab Resp Dis, Guangzhou Inst Resp Hlth, Affiliated Hosp 1,Natl Clin Res Ctr Resp Dis, Guangzhou, Peoples R China

[4] Univ Chinese Acad Sci, BGI Educ Ctr, Shenzhen, Peoples R China

[5] Guangzhou Med Univ, SInst Infect Dis, Guangzhou Peoples Hosp 8, Guangzhou, Peoples R China

[6] South China Univ Technol, Sch Biol & Biol Engn, Guangzhou, Peoples R China

[7] Sun Yat Sen Univ, Guangdong Prov Engn Res Ctr Mol Imaging, Affiliated Hosp 5,Dept Infect Dis, Guangdong Prov Key Lab Biomed Imaging, Zhuhai, Peoples R China

[8] Guangzhou Med Univ, Affiliated Hosp 6, Qingyuan Peoples Hosp, Qingyuan, Peoples R China

[9] Yangiang Peoples Hosp, Yangjiang, Peoples R China

[10] Univ Copenhagen, Lab Genom & Mol Biomed, Dept Biol, Copenhagen, Denmark

[11] BGI Shenzhen, Shenzhen Key Lab Genom, Guangdong Prov Key Lab Human Dis Genom, Shenzhen, Peoples R China

[12] BGI Shenzhen, BGI PathoGenesis Pharmaceut Technol, Shenzhen, Peoples R China

[13] BGI Shenzhen, Shenzhen Engn Lab Innovat Mol Diagnost, Shenzhen, Peoples R China

[14] BGI Shenzhen, Guangdong Prov Key Lab Genome Read & Write, Shenzhen, Peoples R China

来源：

FRONTIERS IN MEDICINE | 2021年 / 8卷

关键词：

SARS-CoV-2; population bottleneck; intra-host variation; human to human transmission; evolution;

D O I：

10.3389/fmed.2021.585358

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The emergence of the novel human coronavirus, SARS-CoV-2, causes a global COVID-19 (coronavirus disease 2019) pandemic. Here, we have characterized and compared viral populations of SARS-CoV-2 among COVID-19 patients within and across households. Our work showed an active viral replication activity in the human respiratory tract and the co-existence of genetically distinct viruses within the same host. The inter-host comparison among viral populations further revealed a narrow transmission bottleneck between patients from the same households, suggesting a dominated role of stochastic dynamics in both inter-host and intra-host evolutions.

引用

页数：7

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