Polymorphisms of DNA base-excision repair genes APE/Ref-1 and XRCC1 are not associated with the risk for Graves' disease

被引:3
|
作者
Dogru-Abbasoglu, Semra [1 ]
Tanrikulu, Sevda [1 ]
Ademoglu, Evin [1 ]
Erbil, Yesim [2 ]
Oezderya, Aysenur [3 ]
Karadag, Berrin [3 ]
Uysal, Muejdat [1 ]
机构
[1] Istanbul Univ, Dept Biochem, Istanbul Fac Med, TR-34093 Istanbul, Turkey
[2] Istanbul Univ, Dept Gen Surg, Istanbul Fac Med, TR-34093 Istanbul, Turkey
[3] Sisli Etfal Hosp, Dept Internal Med, Istanbul, Turkey
关键词
Graves' disease; polymorphism; DNA repair; APE/Ref-1; XRCC1; OXIDATIVE STRESS; CANCER-RISK; APE1; DAMAGE; VARIANTS; APE1/REF-1; GENOTYPE; XPD;
D O I
10.1002/cbf.1595
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Oxidative stress has been implicated in etiopathogenesis of Graves' disease (GD). Increased lipid peroxidation and oxidative DNA damage have been found in GD patients. Oxidative DNA damage is mainly repaired by the base-excision repair (BER) pathway. Polymorphisms in DNA-repair genes have been associated with the increased risk of various diseases and could also be related to the etiology of GD. Therefore, we conducted a study including 197 patients with GD and age- and sex-matched 303 healthy subjects to examine the role of single-nucleotide polymorphisms of BER genes, APE/Ref-1 (codon 148) and XRCC1 (codons 194 and 399) as a risk factor for GD. These polymorphisms were determined by quantitative real-time PCR and melting curve analysis using LightCycler. No significant association was observed between the variant alleles of APE/Ref-1 codon 148 [odds ratio (OR) = 0.89, 95% confidence interval (CI) = 0.69-1.17], XRCC1 codon 194 (OR = 1.24, 95% CI = 0.79-1.94), and XRCC1 codon 399 (OR = 1.12, 95% CI = 0.86-1.46) and GD. These preliminary results suggest that APE/Ref-1 (codon 148) and XRCC1 (codons 194 and 399) polymorphisms are not significant risk factors for developing GD. Copyright (C) 2009 John Wiley & Sons, Ltd.
引用
收藏
页码:462 / 467
页数:6
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