GRK6 over-expression predicts poor outcomes in patients with lung adenocarcinoma

被引：0

作者：

Jiang, Yuanzhu ^{[1
]}

Wang, Chao ^{[2
]}

Zhao, Yang ^{[3
]}

Shen, Hongchang ^{[4
]}

机构：

[1] Shandong Univ, Prov Hosp, Dept Thorac Surg, Jinan 250021, Peoples R China

[2] Shandong Univ, Dept Resp Med, Shandong Prov Qianfoshan Hosp, Jinan 250021, Peoples R China

[3] Shandong Univ, Inst Oncol, Prov Hosp, Jinan 250021, Peoples R China

[4] Shandong Univ, Dept Oncol, Prov Hosp, 324 Jingwu Rd, Jinan 250021, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2016年 / 9卷 / 01期

基金：

中国国家自然科学基金;

关键词：

GRK6; lung adenocarcinoma; prognosis; COUPLED RECEPTOR KINASE; PROTEIN; REGULATORS; ARRESTINS; MIGRATION;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objective is to investigate the expression and potential roles of G protein-coupled receptor kinase 6 (GRK6) in lung adenocarcinoma patients. Immunohistochemistry was performed to determine GRK6 expression in 196 lung adenocarcinoma samples. And the relationship between expression and clinicopathological features was analyzed. Lung adenocarcinoma patients with higher GRK6 expression had poor outcomes. And GRK6 high expression was associated with metastasis and relapse. GRK6 overexpression may be a significant independent prognostic factor of lung adenocarcinoma.

引用

页码：159 / 164

页数：6

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