High concentrations of nelfinavir as an independent risk factor for lipodystrophy in human immunodeficiency virus-infected patients

被引：15
|
作者：
Tréluyer, JM [1 ]
Morini, JP [1 ]
Dimet, J [1 ]
Gorin, I [1 ]
Rey, E [1 ]
Deleuze, J [1 ]
Ceccaldi, PF [1 ]
Escande, JP [1 ]
Pons, G [1 ]
Dupin, N [1 ]
机构：
[1] Univ Paris 05, Grp Hosp Cochin St Vincnet De Paul, AP HP, F-75674 Paris 14, France
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 12期
关键词：
D O I：
10.1128/AAC.46.12.4009-4012.2002
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
To assess the relationship between antiretroviral drug exposure and lipodystrophy, 69 human immunodeficiency virus type 1-infected patients receiving nelfinavir were investigated cross-sectionally. Lipodystrophy was defined by patients' self-report. Nelfinavir trough concentrations in plasma were significantly related to overall lipodystrophy and peripheral fat wasting scores and appeared to be an independent risk factor for lipodystrophy.
引用
收藏
页码：4009 / 4012
页数：4
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