Racial and ethnic disparities in health care-associated Clostridium difficile infections in the United States: State of the science

Background: Among health care-associated infections (HAIs), Clostridium difficile infections (CDIs) are a major cause of morbidity and mortality in the United States. As national progress toward CDI prevention continues, it will be critical to ensure that the benefits from CDI prevention are realized across different patient demographic groups, including any targeted interventions. Methods: Through a comprehensive review of existing evidence for racial/ethnic and other disparities in CDIs, we identified a few general trends, but the results were heterogeneous and highlight significant gaps in the literature. Results: The majority of analyzed studies identified white patients as at increased risk of CDIs, although there is a very limited literature base, and many studies had significant methodological limitations. Conclusion: Key recommendations for future research are provided to address antimicrobial stewardship programs and populations that may be at increased risk for CDIs. Published by Elsevier Inc. on behalf of the Association for Professionals in Infection Control and Epidemiology, Inc.