Combination cytokine therapy: The next generation of rheumatoid arthritis therapy?

The approach to treatment of RA has undergone a paradigm shift. The considerable efficacy seen with TNF inhibitors has invigorated clinicians, stimulating them to redouble their efforts to control rheumatoid inflammation. A number of exciting avenues, such as combination cytokine therapy, may allow us to achieve the goal of eradicating disease activity. If the promising results from early animal studies of combination cytokine therapy can be reproduced in trials in RA, we may be able to achieve true disease modification and even remission for many of our patients with RA. Further developments in this area are eagerly awaited.