Coronary artery disease risk among obese metabolically healthy young men

被引:18
|
作者
Twig, Gilad [1 ,2 ,3 ]
Gerstein, Hertzel C. [4 ,5 ]
Shor, Dana Ben-Ami [1 ]
Derazne, Estela [3 ,6 ]
Tzur, Dorit [3 ]
Afek, Arnon [6 ,7 ]
Tirosh, Amir [2 ,8 ,9 ]
机构
[1] Chaim Sheba Med Ctr, Dept Med B, IL-52621 Ramat Gan, Israel
[2] Chaim Sheba Med Ctr, Dr Pinchas Bornstein Talpiot Med Leadership Progr, IL-52621 Ramat Gan, Israel
[3] Israel Def Forces Med Corps, Ramat Gan, Israel
[4] McMaster Univ, Populat Hlth Res Inst, Div Endocrinol & Metab, Hamilton, ON, Canada
[5] Hamilton Hlth Sci, Hamilton, ON, Canada
[6] Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel
[7] Israel Minist Hlth, Jerusalem, Israel
[8] Chaim Sheba Med Ctr, Dept Endocrinol, IL-52621 Ramat Gan, Israel
[9] Harvard Univ, Brigham & Womens Hosp, Div Endocrinol Diabet & Hypertens, Sch Med, Boston, MA 02115 USA
关键词
BODY-MASS INDEX; CARDIOVASCULAR-DISEASE; HEART-DISEASE; INSULIN-RESISTANCE; ALL-CAUSE; MORTALITY; ADULTS; WEIGHT; BMI; INDIVIDUALS;
D O I
10.1530/EJE-15-0284
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: The aim of this study was to assess coronary artery disease (CAD) risk among obese young men without metabolic risk factors. Design: A longitudinal study in a historical cohort. Methods: Incident CAD during a median follow-up of 6.1 years was assessed among 31 684 young men (mean age 31.2 +/- 5.7 years) of the Metabolic, Lifestyle and Nutrition Assessment in Young Adults (MELANY) cohort. Participants were categorized by BMI and the number of metabolic abnormalities (based on the Adult Treatment Panel-III). Metabolically healthy (MH) obesity was defined as BMI >= 30 kg/m(2) in the presence of normal blood pressure (BP) and normal levels of fasting glucose, triglyceride, and HDL-cholesterol (HDL-c) levels (n=599; 1.9%). Cox proportional hazard models were applied. Results: There were 198 new cases of CAD that were diagnosed during 209 971 person-years of follow-up, of which six cases occurred among MH obese. The incidence of CAD among MH lean, overweight, and obese participants was 0.23, 0.45, and 1.0/1000 person-years respectively. In a multivariable model adjusted for clinical and biochemical CAD risk factors, a higher CAD risk was observed among MH-obese (hazard ratio=3.08; 95% CI=1.10-8.68, P=0.033), compared to MH-normal weight subjects. This risk persisted when BMI was treated as a time-dependent variable, or when fasting glucose, HDL-c, triglycerides, or BP were added to the model. Similar results were also obtained when a more permissive definition of MH was used. Conclusions: Obesity may continue to contribute to increased risk for incident CAD in young men even in the presence of a healthy metabolic profile.
引用
收藏
页码:305 / 312
页数:8
相关论文
共 50 条
  • [1] Heart disease risk among metabolically healthy obese men and metabolically unhealthy lean men
    Janssen, I
    [J]. CANADIAN MEDICAL ASSOCIATION JOURNAL, 2005, 172 (10) : 1315 - 1316
  • [2] Diabetes Risk Among Overweight and Obese Metabolically Healthy Young Adults
    Twig, Gilad
    Afek, Arnon
    Derazne, Estela
    Tzur, Dorit
    Cukierman-Yaffe, Tali
    Gerstein, Hertzel C.
    Tirosh, Amir
    [J]. DIABETES CARE, 2014, 37 (11) : 2989 - 2995
  • [3] Sleep quality and risk of diabetes and coronary artery disease among young men
    Twig, Gilad
    Shina, Avi
    Afek, Arnon
    Derazne, Estela
    Tzur, Dorit
    Cukierman-Yaffe, Tali
    Shechter-Amir, Dalia
    Gerstein, Hertzel C.
    Tirosh, Amir
    [J]. ACTA DIABETOLOGICA, 2016, 53 (02) : 261 - 270
  • [4] Sleep quality and risk of diabetes and coronary artery disease among young men
    Gilad Twig
    Avi Shina
    Arnon Afek
    Estela Derazne
    Dorit Tzur
    Tali Cukierman-Yaffe
    Dalia Shechter-Amir
    Hertzel C. Gerstein
    Amir Tirosh
    [J]. Acta Diabetologica, 2016, 53 : 261 - 270
  • [5] Fatty liver disease determines the progression of coronary artery calcification in a metabolically healthy obese population
    Kang, Yu Mi
    Jung, Chang Hee
    Cho, Yun Kyung
    Lee, Seung Eun
    Lee, Min Jung
    Hwang, Jenie Yoonoo
    Kim, Eun Hee
    Park, Joong-Yeol
    Lee, Woo Je
    Kim, Hong-Kyu
    [J]. PLOS ONE, 2017, 12 (04):
  • [6] Fatty Liver Disease Determines the Progression of Coronary Artery Calcification in a Metabolically Healthy Obese Population
    Jung, Chang Hee
    Kang, Yu Mi
    Cho, Yun Kyung
    Lee, Seung Eun
    Lee, Min Jung
    Hwang, Jenie Yoonoo
    Kim, Eun Hee
    Park, Joong Yeol
    Lee, Woo Je
    Kim, Hong Kyu
    [J]. DIABETES, 2017, 66 : A114 - A114
  • [7] Fatty liver disease determines the progression of coronary artery calcification in a metabolically healthy obese population
    Lee, W.
    Kang, Y.
    Jung, C.
    Cho, Y.
    Lee, S.
    Hwang, J.
    Kim, E.
    Park, J. -Y.
    Kim, H. -K.
    [J]. DIABETOLOGIA, 2017, 60 : S6 - S7
  • [8] Metabolically Healthy Obese and Incident Cardiovascular Disease Events Among 3.5 Million Men and Women
    Caleyachetty, Rishi
    Thomas, G. Neil
    Toulis, Konstantinos A.
    Mohammed, Nuredin
    Gokhale, Krishna M.
    Balachandran, Kumarendran
    Nirantharakumar, Krishnarajah
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2017, 70 (12) : 1429 - 1437
  • [9] Effects of Weight Loss Among Metabolically Healthy Obese Men and Women
    Janiszewski, Peter M.
    Ross, Robert
    [J]. DIABETES CARE, 2010, 33 (09) : 1957 - 1959
  • [10] Leptin as a cardiovascular risk marker in metabolically healthy obese Hyperleptinemia in metabolically healthy obese
    Jamar, Giovana
    Caranti, Danielle Arisa
    Cesar, Helena de Cassia
    Landi Masquio, Deborah Cristina
    Bandoni, Daniel Henrique
    Pisani, Luciana Pellegrini
    [J]. APPETITE, 2017, 108 : 477 - 482