Smoking and low antioxidant levels increase oxidative damage to sperm DNA

被引：325
|
作者：
Fraga, CG
Motchnik, PA
Wyrobek, AJ
Rempel, DM
Ames, BN
机构：
[1] UNIV CALIF BERKELEY, DIV BIOCHEM & MOLEC BIOL, BERKELEY, CA 94720 USA
[2] UNIV BUENOS AIRES, FAC FARM & BIOQUIM, RA-1113 BUENOS AIRES, DF, ARGENTINA
[3] LAWRENCE LIVERMORE NATL LAB, LIVERMORE, CA 94551 USA
[4] UNIV CALIF SAN FRANCISCO, DIV ENVIRONM & OCCUPAT MED, SAN FRANCISCO, CA 94143 USA
来源：
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 1996年 / 351卷 / 02期
关键词：
8-oxo-deoxyguanosine; ascorbate; tocopherol;
D O I：
10.1016/0027-5107(95)00251-0
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Our previous studies have shown that men with low ascorbate intake have markedly increased oxo(8)dG in the DNA of their sperm. Because cigarette smoke is high in oxidants and depletes plasma and tissue antioxidants, oxidative DNA damage in sperm and tocopherol and ascorbate levels in seminal plasma were determined in smokers and non-smokers. The level in sperm DNA of oxo(8)dG, an oxidative lesion of guanine, was 50% higher in smokers compared to non-smokers (p = 0.005). The concentration of cr-tocopherol in seminal plasma was decreased in smokers by 32% (p = 0.03). Smoking and low antioxidant levels increase oxidative damage to sperm DNA. We discuss the possibility that paternal smoking causes mutations in sperm that lead to cancer, birth defects, and genetic diseases in offspring.
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页码：199 / 203
页数：5
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