Synthesis and Antimicrobial Activity of New Thiazolidine-Based Heterocycles as Rhodanine Analogues

A new series of compounds containing thiazole nucleus as Rhodanine analogues have been synthesized. The new compounds were prepared from the reactions of the thiosemicarbazones (3a,b) with a series of -halo carbonyl compounds to give the corresponding Rhodanine analogues. The thiosemicarbazones derivatives (3a,b) were reacted also with hydrazonoyl chlorides to afford the corresponding tri-substituted and tetra-substituted thiazoles. The structures of the newly synthesized compounds were confirmed by elemental analysis and spectral data. The biological activities of the new synthesized Rhodanine analogues' were evaluated for their antimicrobial activities. The results showed that some of these compounds showed excellent activity against two fungal strains, including Aspergillus niger and Aspergillus flavus, in addition to three yeast strains, including Saccharomyces cervesi, Candida albicans NRRL Y-477, and Candida Pathological specimen compared with the ketoconazol, as the reference drug.