The Mechanics of Single Cell and Collective Migration of Tumor Cells

被引:103
|
作者
Lintz, Marianne [1 ]
Munoz, Adam [1 ]
Reinhart-King, Cynthia A. [1 ]
机构
[1] Cornell Univ, Nancy E & Peter C Meinig Sch Biomed Engn, 309 Weill Hall, Ithaca, NY 14853 USA
基金
美国国家科学基金会;
关键词
BREAST-CANCER CELLS; MATRIX STIFFNESS; SUBSTRATE INTERFACE; NUCLEAR-DEFORMATION; PHYSICAL-PROPERTIES; CARCINOMA-CELLS; LEADER CELLS; INVASION; ADHESION; MODEL;
D O I
10.1115/1.4035121
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Metastasis is a dynamic process in which cancer cells navigate the tumor microenvironment, largely guided by external chemical and mechanical cues. Our current understanding of metastatic cell migration has relied primarily on studies of single cell migration, most of which have been performed using two-dimensional (2D) cell culture techniques and, more recently, using three-dimensional (3D) scaffolds. However, the current paradigm focused on single cell movements is shifting toward the idea that collective migration is likely one of the primary modes of migration during metastasis of many solid tumors. Not surprisingly, the mechanics of collective migration differ significantly from single cell movements. As such, techniques must be developed that enable in-depth analysis of collective migration, and those for examining single cell migration should be adopted and modified to study collective migration to allow for accurate comparison of the two. In this review, we will describe engineering approaches for studying metastatic migration, both single cell and collective, and how these approaches have yielded significant insight into the mechanics governing each process.
引用
收藏
页数:9
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