Efficient and Selective Construction of Pyrrolo[3,2-d]pyrimidine Derivatives

被引：0

作者：

He, Ping ^{[1
]}

Wu, Jing ^{[1
]}

Hu, Yang-Gen ^{[2
]}

Li, Zai-Fang ^{[1
]}

Hou, Qiu-Fei ^{[1
]}

Wang, Yan-Ling ^{[1
]}

Zhao, Kun ^{[1
]}

Zhang, Erli ^{[1
]}

机构：

[1] Hubei Univ Arts & Sci, Coll Chem Engn & Food Sci, Xiangyang 441053, Peoples R China

[2] Hubei Univ Med, Inst Med Chem, Shiyan 442000, Peoples R China

来源：

BULLETIN OF THE KOREAN CHEMICAL SOCIETY | 2014年 / 35卷 / 02期

基金：

湖北省教育厅重点项目; 中国国家自然科学基金;

关键词：

Pyrrolo[3,2-d]pyrimidine; Aza-Wittig reaction; Iminophosphorane; 1,3,4-OXADIAZOLE DERIVATIVES; ONE-POT; INHIBITOR;

D O I：

10.5012/bkcs.2014.35.2.617

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient and selective method for the synthesis of ethyl 2-amino/aryloxy-3-aryl-4-oxo-5-phenyl-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidine-7-carboxylate derivatives has been developed. The main process involved the reaction of diethyl 1-phenyl-3-((triphenylphosphoranylidene)amino)-1H-pyrrole-2,4-dicarboxylate and aromatic isocyanates, followed by addition of amines/phenols in the presence of catalytic amount of sodium ethoxide or solid potassium carbonate.

引用

页码：617 / 621

页数：5

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