Intrapatient emergence of OXA-247: a novel carbapenemase found in a patient previously infected with OXA-163-producing Klebsiella pneumoniae

被引：48
|
作者：
Gomez, S. [1 ,2 ]
Pasteran, F. [1 ]
Faccone, D. [1 ]
Bettiol, M. [3 ]
Veliz, O. [1 ]
De Belder, D. [1 ]
Rapoport, M. [1 ]
Gatti, B. [3 ]
Petroni, A. [1 ]
Corso, A. [1 ]
机构：
[1] Inst Nacl Enfermedades Infecciosas INEI ANLIS Dr, Serv Antimicrobianos, Buenos Aires, DF, Argentina
[2] CONICET Consejo Nacl Invest Cient & Tecn, Buenos Aires, DF, Argentina
[3] Hosp Ninos Sor Maria Ludvica La Plata, La Plata, Buenos Aires, Argentina
来源：
CLINICAL MICROBIOLOGY AND INFECTION | 2013年 / 19卷 / 05期
关键词：
Carbapenemase; CHDL; Klebsiella pneumoniae; OXA-163; OXA-48; BETA-LACTAMASES; RESISTANCE; ARGENTINA; ENTEROBACTERIACEAE; COMBINATION; PLASMIDS;
D O I：
10.1111/1469-0691.12142
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Two genetically related Klebsiella pneumoniae strains carrying OXA-type carbapenemases were isolated from a single patient 1 month apart. Kpn163 harboured OXA-163 and Kpn247 a new variant named OXA-247 that showed susceptibility to carbapenems and expanded-spectrum cephalosporins similar to OXA-48. Our epidemiological, biochemical and molecular results suggest the intrapatient emergence of blaOXA-247 from blaOXA-163.
引用
收藏
页码：E233 / E235
页数：3
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