Toxoplasmosis with hemophagocytic syndrome after bone marrow transplantation: diagnosis at autopsy

被引：27
|
作者：
Duband, S. [1 ,2 ]
Cornillon, J. [3 ]
Tavernier, E. [3 ]
Dumollard, J. -M. [1 ,2 ]
Guyotat, D. [3 ]
Peoc'h, M. [1 ,2 ]
机构：
[1] Univ St Etienne, Dept Pathol, Ctr Hosp, Bellevue Hosp, F-42055 St Etienne 2, France
[2] Univ St Etienne, Res Unit JE Biol Ingn & Imagerie Greffe Cornee 25, BiiGC, Jacques Lisfranc Fac Med, F-42055 St Etienne 2, France
[3] Univ St Etienne, Dept Hematol, Ctr Hosp, Bellevue Hosp, F-42055 St Etienne 2, France
来源：
TRANSPLANT INFECTIOUS DISEASE | 2008年 / 10卷 / 05期
关键词：
toxoplasmosis; autopsy; hemophagocytic syndrome; bone marrow transplantation;
D O I：
10.1111/j.1399-3062.2008.00310.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Toxoplasmosis is a rare but well recognized opportunistic infection that can occur after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Besides encephalitis, other common presentations of Toxoplasma gondii infection are interstitial pneumonitis and myocarditis. Because of its non-specific clinical and biological signs and its lethal outcome, toxoplasmosis is often misdiagnosed and only revealed at autopsy. We report a case of a postmortem diagnosis of disseminated toxoplasmosis associated with hemophagocytic syndrome, which underlines the value of necropsy in cases of death after transplantation. We also discuss clinical presentations and risk factors that lead to toxoplasmosis in allo-HSCT recipients.
引用
收藏
页码：372 / 374
页数：3
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