Role of P-Glycoprotein in Norbuprenorphine Transport at the Blood-Brain Barrier in Mice: Considerations for Buprenorphine Respiratory Toxicity

被引:0
|
作者
Alhaddad, H. [1 ]
Cisternino, S. [1 ]
Risede, P. [1 ]
Baud, F. J. [1 ,2 ]
Megarbane, B. [1 ,2 ]
机构
[1] Paris Descartes Univ, INSERM, U705, Paris, France
[2] Hop Lariboisiere, Dept Med & Toxicol Crit Care, F-75475 Paris, France
关键词
D O I
暂无
中图分类号
R99 [毒物学(毒理学)];
学科分类号
100405 ;
摘要
231
引用
收藏
页码:335 / 335
页数:1
相关论文
共 50 条
  • [1] Respiratory toxicity of buprenorphine results from the blockage of P-glycoprotein-mediated efflux of norbuprenorphine at the blood-brain barrier in mice
    Alhaddad, Hisham
    Cisternino, Salvatore
    Decleves, Xavier
    Tournier, Nicolas
    Schlatter, Joel
    Chiadmi, Fouad
    Risede, Patricia
    Smirnova, Maria
    Besengez, Capucine
    Scherrmann, Jean-Michel
    Baud, Frederic J.
    Megarbane, Bruno
    CRITICAL CARE MEDICINE, 2012, 40 (12) : 3215 - 3223
  • [2] RESPIRATORY TOXICITY OF BUPRENORPHINE RESULTS FROM THE BLOCKAGE OF P-GLYCOPROTEIN-MEDIATED EFFLUX OF NORBUPRENORPHINE AT THE BLOOD-BRAIN BARRIER IN MICE
    Megarbane, B.
    Alhaddad, H.
    Cistemino, S.
    Risede, P.
    Baud, F. J.
    INTENSIVE CARE MEDICINE, 2012, 38 : S208 - S208
  • [3] Buprenorphine and Norbuprenorphine-Related Respiratory Effects in Mice: Role of P-Glycoprotein Transporter
    Alhaddad, H.
    Cisternino, S.
    Vodovar, D.
    Decleves, X.
    Risede, P.
    Baud, F. J.
    Megarbane, B.
    CLINICAL TOXICOLOGY, 2011, 49 (03) : 220 - 220
  • [4] BUPRENORPHINE AND NORBUPRENORPHINE-RELATED RESPIRATORY EFFECTS IN MICE: ROLE OF P-GLYCOPROTEIN TRANSPORTER
    Alhaddad, H.
    Cisternino, S.
    Risede, P.
    Baud, F. J.
    Megarbane, B.
    INTENSIVE CARE MEDICINE, 2011, 37 : S51 - S51
  • [5] Buprenorphine and norbuprenorphine-related respiratory effects in mice: Role of p-glycoprotein transporter
    Alhaddad, H.
    Cisternino, S.
    Risede, P.
    Vodovar, D.
    Baud, F.
    Megarbane, B.
    TOXICOLOGY LETTERS, 2011, 205 : S184 - S184
  • [6] P-glycoprotein mediates brain-to-blood efflux transport of buprenorphine across the blood-brain barrier
    Suzuki, Toyofumi
    Zaima, Chika
    Moriki, Yoshiaki
    Fukami, Toshiro
    Tomono, Kazuo
    JOURNAL OF DRUG TARGETING, 2007, 15 (01) : 67 - 74
  • [7] The Role of P-Glycoprotein in Transport of Danshensu across the Blood-Brain Barrier
    Yu, Peng-Fei
    Wang, Wen-Yan
    Eerdun, Gaowa
    Wang, Tian
    Zhang, Lei-Ming
    Li, Chong
    Fu, Feng-Hua
    EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2011, 2011 : 1 - 5
  • [8] P-Glycoprotein on Blood-Brain Barrier Plays a Vital Role in Fentanyl Brain Exposure and Respiratory Toxicity in Rats
    Yu, Chenchen
    Yuan, Mei
    Yang, Haiying
    Zhuang, Xiaomei
    Li, Hua
    TOXICOLOGICAL SCIENCES, 2018, 164 (01) : 353 - 362
  • [9] The functional role of P-glycoprotein in the blood-brain barrier
    vanAsperen, J
    Mayer, U
    vanTellingen, O
    Beijnen, JH
    JOURNAL OF PHARMACEUTICAL SCIENCES, 1997, 86 (08) : 881 - 884
  • [10] P-glycoprotein regulated transport of glutamate at blood-brain barrier
    Liu, XD
    Liu, GQ
    ACTA PHARMACOLOGICA SINICA, 2001, 22 (02): : 111 - 116