Hepatitis E virus infections in HIV-infected patients in Ghana and Cameroon

被引:47
|
作者
Feldt, Torsten [1 ,2 ]
Sarfo, Fred Stephen [3 ]
Zoufaly, Alexander [4 ]
Phillips, Richard Odame [3 ,5 ]
Burchard, Gerd [1 ,4 ]
van Lunzen, Jan [4 ]
Jochum, Johannes [4 ]
Chadwick, David [6 ]
Awasom, Charles [7 ]
Claussen, Lisa [1 ]
Drosten, Christian [8 ]
Drexler, Jan Felix [8 ]
Eis-Huebinger, Anna Maria [8 ]
机构
[1] Bernhard Nocht Inst Trop Med, Clin Res Unit, D-20359 Hamburg, Germany
[2] Univ Hosp Dusseldorf, Dept Gastroenterol Hepatol & Infect Dis, D-40225 Dusseldorf, Germany
[3] Komfo Anokye Teaching Hosp, Directorate Med, Kumasi, Ghana
[4] Univ Med Ctr Hamburg Eppendorf, Infect Dis Unit, Dept Med 1, D-20246 Hamburg, Germany
[5] Kwame Nkrumah Univ Sci & Technol, Kumasi, Ghana
[6] James Cook Univ Hosp, Ctr Clin Infect, Middlesbrough TS4 3BW, Cleveland, England
[7] Northwest Reg Hosp, Bamenda, Northwest Regio, Cameroon
[8] Univ Bonn, Med Ctr, Inst Virol, D-53127 Bonn, Germany
关键词
HIV; HEV; Chronic hepatitis; Seroprevalence; Africa south of the Sahara; HUMAN-IMMUNODEFICIENCY-VIRUS; TRANSPLANT RECIPIENTS; DEVELOPED-COUNTRIES; PREGNANT-WOMEN; BLOOD-DONORS; PREVALENCE; SEROPREVALENCE; ANTIBODIES; HEV; EPIDEMIOLOGY;
D O I
10.1016/j.jcv.2013.05.004
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Background: Chronic hepatitis E virus (HEV) infections have recently been described in HIV-infected patients. Only few data are available for sub-Saharan Africa, where HIV and HEV are highly co-endemic, and where liver pathology is common in HIV-infected individuals. Objectives: To assess the prevalence of HEV viremia, anti-HEV antibodies, and serum aminotransferase levels in HIV patients in Ghana and Cameroon. Study design: We retrospectively surveyed a cross-section of patients who were enrolled in cohort studies in Ghana (West Africa), and Cameroon (Central Africa). Plasma samples from 1029 HIV patients from Ghana and 515 patients from Cameroon including 214 children were analyzed for HEV-RNA by two reverse transcription PCR methods. In a subset of 791 patients, anti-HEV IgG and IgM antibodies were analyzed. Results: No HEV-RNA was detected in any of the plasma samples of 1544 patients. HEV seroprevalence was high in adult HIV patients from Ghana (45.3%, n = 402) and Cameroon (14.2%, n = 289), but low in pediatric HIV patients from Cameroon (2.0%, n = 100). Elevations of alanine aminotransferase and aspartate aminotransferase levels were common in adult patients from Ghana (20.8% and 25.4%) and Cameroon (38.9% and 69.8%). The prevalence of hepatitis B virus surface antigen was 11.8% and of hepatitis C virus antibodies 2.5% in our adult Cameroonian study population. Conclusions: Acute or chronic HEV infections did not play a role in liver pathology in two HIV cohorts in Ghana and Cameroon. A better understanding of the epidemiology and genotype-specific characteristics of HEV infections in HIV patients in sub-Saharan Africa is needed. (C) 2013 Elsevier B. V. All rights reserved.
引用
收藏
页码:18 / 23
页数:6
相关论文
共 50 条
  • [1] Hepatitis E virus in HIV-infected patients
    Renou, Christophe
    Lafeuillade, Alain
    Cadranel, Jean-Francois
    Pavio, Nicole
    Pariente, Alexandre
    Allegre, Thierry
    Poggi, Cecile
    Penaranda, Guillaume
    Cordier, Francois
    Nicand, Elisabeth
    [J]. AIDS, 2010, 24 (10) : 1493 - 1499
  • [2] Seroprevalence of hepatitis E virus in HIV-infected patients in China
    Zeng, Hang
    Wang, Lin
    Liu, Peng
    Liao, Lingjie
    Wang, Ling
    Shao, Yiming
    [J]. AIDS, 2017, 31 (14) : 2019 - 2021
  • [3] SEROLOGICAL AND VIROLOGICAL SURVEY OF HEPATITIS E VIRUS IN HIV-INFECTED PATIENTS
    Renou, Christophe
    Lafeuillade, Alain
    Pariente, Alexandre
    Cadranel, Jean-Francois
    Pavio, Nicole
    Allegre, Thierry
    Wartelle-Bladou, Claire
    Gaillat, Jacques
    Heluwaert, Frederic
    Poggi, Cecile B.
    Penaranda, Guillaume
    Nicand, Elisabeth
    [J]. HEPATOLOGY, 2009, 50 (04) : 733A - 733A
  • [4] Antibody to hepatitis E virus in HIV-infected individuals and AIDS patients
    Balayan, MS
    Fedorova, OE
    Mikhailov, MI
    Rytick, PG
    Eremin, VF
    Danilova, TI
    Shevelev, BI
    Gorbacheva, EC
    Pankova, GY
    [J]. JOURNAL OF VIRAL HEPATITIS, 1997, 4 (04) : 279 - 283
  • [5] Hepatitis E Virus Infection in HIV-infected Persons
    Crum-Cianflone, Nancy F.
    Curry, Jennifer
    Drobeniuc, Jan
    Weintrob, Amy
    Landrum, Michael
    Ganesan, Anuradha
    Bradley, William
    Agan, Brian K.
    Kamili, Saleem
    [J]. EMERGING INFECTIOUS DISEASES, 2012, 18 (03) : 502 - 506
  • [6] Hepatitis E Infection in HIV-Infected Patients
    Rivero-Juarez, Antonio
    Lopez-Lopez, Pedro
    Frias, Mario
    Rivero, Antonio
    [J]. FRONTIERS IN MICROBIOLOGY, 2019, 10
  • [7] Opportunistic infections in HIV-infected individuals: hepatitis C virus
    Talal, A
    [J]. LANCET, 2002, 360 (9333): : 584 - 586
  • [8] Hepatitis C virus infection in HIV-infected patients
    Mark S. Sulkowski
    [J]. Current Hepatitis Reports, 2002, 1 (1) : 16 - 22
  • [9] Hepatitis C virus infection in HIV-infected patients
    Mark S. Sulkowski
    [J]. Current Infectious Disease Reports, 2001, 3 (5) : 469 - 476
  • [10] Epidemiology of hepatitis C virus in HIV-infected patients
    Peters, Lars
    Klein, Marina B.
    [J]. CURRENT OPINION IN HIV AND AIDS, 2015, 10 (05) : 297 - 302