Nuclear imaging of neuroinflammation: a comprehensive review of [11C]PK11195 challengers

被引:343
|
作者
Chauveau, Fabien [1 ,2 ]
Boutin, Herve [3 ]
Van Camp, Nadja [1 ,2 ]
Dolle, Frederic [1 ]
Tavitian, Bertrand [1 ,2 ]
机构
[1] CEA, Serv Hosp Frederic Joliot, Inst Imagerie BioMed, Lab Imagerie Mol Expt, F-91406 Orsay, France
[2] Univ Paris 11, INSERM, U803, F-91405 Orsay, France
[3] Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England
关键词
Neuroinflammation; PET; C-11]PK11195; Peripheral benzodiazepine receptor (PBR); Translocator protein 18kDa (TSPO);
D O I
10.1007/s00259-008-0908-9
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Neurodegenerative, inflammatory and neoplastic brain disorders involve neuroinflammatory reactions, and a biomarker of neuroinflammation would be useful for diagnostic, drug development and therapy control of these frequent diseases. In vivo imaging can document the expression of the peripheral benzodiazepine receptor (PBR)/translocator protein 18 kDa (TSPO) that is linked to microglial activation and considered a hallmark of neuroinflammation. The prototype positron emission tomography tracer for PBR, [C-11]PK11195, has shown limitations that until now have slowed the clinical applications of PBR imaging. In recent years, dozens of new PET and SPECT radioligands for the PBR have been radio-labelled, and several have been evaluated in imaging protocols. Here we review the new PBR ligands proposed as challengers of [C-11]PK11195, critically analyze preclinical imaging studies and discuss their potential as neuroinflammation imaging agents.
引用
收藏
页码:2304 / 2319
页数:16
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