Reflex myoclonic epilepsy in infancy: A multicenter clinical study

被引：8

作者：

Verrotti, Alberto ^{[1
]}

Matricardi, Sara ^{[1
]}

Capovilla, Giuseppe ^{[2
]}

D'Egidio, Claudia ^{[1
]}

Cusmai, Raffaella ^{[3
]}

Romeo, Antonino ^{[4
]}

Pruna, Dario ^{[5
]}

Pavone, Piero ^{[6
]}

Cappanera, Silvia ^{[7
]}

Granata, Tiziana ^{[8
]}

Gobbi, Giuseppe ^{[9
]}

Striano, Pasquale ^{[10
]}

Grosso, Salvatore ^{[11
]}

Parisi, Pasquale ^{[12
]}

Franzoni, Emilio ^{[13
]}

Striano, Salvatore ^{[14
]}

Spalice, Alberto ^{[15
]}

Marino, Raffaella ^{[1
]}

Vigevano, Federico ^{[3
]}

Coppola, Giangennaro ^{[16
]}

机构：

[1] Univ G dAnnunzio, Dept Pediat, I-66100 Chieti, Italy

[2] C Poma Hosp, Dept Child Neuropsychiat, Epilepsy Ctr, Mantua, Italy

[3] Bambino Gesu Pediat Hosp, IRCCS, Div Neurol, Neurol Unit, Rome, Italy

[4] Fatebenefratelli & Oftalm Hosp, Dept Child Neuropsychiat & Neurophysiol, Epilepsy Ctr, Milan, Italy

[5] Azienda Osped Univ Cagliari, Div Child Neurol & Psychiat, Cagliari, Italy

[6] Univ Hosp Vittorio Emanuele Policlin Catania, Dept Pediat & Pediat Emergency Costanza Gravina, Catania, Italy

[7] Osped Riuniti Ancona, Dept Pediat Neurol, Ancona, Italy

[8] IRCCS Fdn Neurol Inst C Besta, Dept Paediat Neurosci, Milan, Italy

[9] Maggiore Hosp Bologna, Dept Neurosci, Child Neurol & Psychiat Unit, Bologna, Italy

[10] Univ Genoa, G Gaslini Inst, Muscular & Neurodegenerat Dis Unit, Genoa, Italy

[11] Univ Siena, Pediat Neurol Unit, Dept Pediat, I-53100 Siena, Italy

[12] Univ Roma La Sapienza, Fac Med 2, Chair Pediat, Rome, Italy

[13] Univ Bologna, S Orsola M Malpighi Hosp, Child Neurol & Psychiat Unit, Bologna, Italy

[14] Univ Naples Federico II, Div Child Neurol, Epilepsy Ctr, Naples, Italy

[15] Univ Roma La Sapienza, Dept Pediat, Rome, Italy

[16] Univ Salerno, Sch Med, Clin Child & Adolescent Neuropsychiat, I-84100 Salerno, Italy

来源：

EPILEPSY RESEARCH | 2013年 / 103卷 / 2-3期

关键词：

Reflex myoclonic epilepsy in infancy; Long-term cognitive outcome; Acoustic and/or tactile stimuli; Valproate treatment; Idiopathic generalized epilepsy; TERM-FOLLOW-UP;

D O I：

10.1016/j.eplepsyres.2012.07.004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Purpose: To describe the clinical and electroencephalographic (EEG) features of reflex myoclonic epilepsy in infancy (RMEI) and long-term cognitive outcome. Methods: We enrolled 31 children from 16 neuropediatric centres in Italy, who underwent clinical and video-EEG evaluation. Cognitive assessment was performed in all patients using standardized psychometric tests. Results: The age at onset ranged from 3 to 24 months of age. Seizures were characterised in all patients by symmetric myoclonic seizures (MS), triggered by sudden unexpected acoustic (38.7%) or tactile stimuli (29%) or both (29%). Spontaneous attacks were reported in 32.2% of the cases. Ictal EEG showed generalized high-amplitude 3 Hz polyspike and wave discharges, synchronous with brief rhythmic bursts of electromyographic activity. Patients were re-evaluated after a period of 7.2 +/- 5.6 years. The prognosis for seizure control was excellent in all cases and reflex MS disappeared spontaneously or after valproate treatment. The cognitive outcome was excellent in 90.3% of children. Conclusions: RMEI appears to be a variety of idiopathic generalized epilepsy with specific features that occurs in developmentally normal children. (c) 2012 Elsevier B.V. All rights reserved.

引用

页码：237 / 244

页数：8

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[1] REFLEX MYOCLONIC EPILEPSY IN INFANCY: A MULTICENTER CLINICAL STUDY
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