EPSTEIN-BARR VIRUS LOAD IN CEREBROSPINAL FLUID OF PATIENTS WITH CHRONIC ACTIVE EPSTEIN-BARR VIRUS INFECTION

被引：6

作者：

Ohga, Shouichi ^{[1
]}

Sanefuji, Masafumi ^{[1
]}

Ishimura, Masataka ^{[1
]}

Nomura, Akihiko ^{[1
]}

Torisu, Hiroyuki ^{[1
]}

Kira, Ryutaro ^{[1
]}

Takada, Hidetoshi ^{[1
]}

Mizuno, Yumi ^{[2
,3
]}

Kazuyama, Yukumasa ^{[4
]}

Hara, Toshiro ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Dept Pediat, Higashi Ku, Fukuoka 8128582, Japan

[2] Fukuoka Childrens Hosp, Div Infect Dis, Fukuoka, Japan

[3] Med Ctr Infect Dis, Fukuoka, Japan

[4] Kitasato Otsuka Biomed Assay Labs Co Ltd, Kanagawa, Japan

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2008年 / 27卷 / 11期

关键词：

Epstein-Barr virus; chronic active Epstein-Barr virus infection; cerebrospinal fluid;

D O I：

10.1097/INF.0b013e318178d21e

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Chronic active Epstein-Barr virus (EBV) infection is a rare chronic mononucleosis syndrome involving clonally proliferating EBV-infected T-/NK-cells. EBV DNA was quantified in nonpleocytotic cerebrospinal fluid (CSF) of 9 patients. Three patients with neurologic and/or neuroimaging abnormalities showed high CSF copy numbers. In I patient, CSF copy number exceeded the peripheral blood value. CSF EBV-load may predict the central nervous system involvement of EBV+T-/NK-cells.

引用

页码：1027 / 1030

页数：4

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