TREATMENT WITH THI, AN INHIBITOR OF SPHINGOSINE-1-PHOSPHATE LYASE (SGPL1), MODULATES GLYCOSPHINGOLIPID METABOLISM AND RESULTS THERAPEUTICALLY EFFECTIVE IN A MOUSE MODEL OF HUNTINGTON'S DISEASE

被引：0

作者：

Pepe, Giuseppe ^{[1
]}

Capocci, Luca ^{[1
]}

Marracino, Federico ^{[1
]}

Realini, Natalia ^{[2
]}

Scarselli, Pamela ^{[1
]}

Di Cicco, Clotilde ^{[1
]}

Armirotti, Andrea ^{[2
]}

Parlato, Rosanna ^{[3
,4
,5
]}

Di Pardo, Alba ^{[1
]}

Maglione, Vittorio ^{[1
]}

机构：

[1] IRCCS Neuromed, Pozzilli, IS, Italy

[2] Fdn Ist Italiano Tecnol, Analyt Chem Lab, Genoa, Italy

[3] Heidelberg Univ, Div Neurodegenerat Dis, Dept Neurol, Mannheim Ctr Translat Neurosci,Med Fac Mannheim, Mannheim, Germany

[4] Heidelberg Univ, Inst Anat & Cell Biol, Heidelberg, Germany

[5] Ulm Univ, Inst Appl Physiol, Ulm, Germany

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 2022年 / 93卷

关键词：

D O I：

10.1136/jnnp-2022-ehdn.244

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

I18

引用

页码：A91 / A91

页数：1

共 47 条

[1] Treatment with THI, an inhibitor of sphingosine-1-phosphate lyase, modulates glycosphingolipid metabolism and results therapeutically effective in models of disease
Pepe, Giuseppe
Capocci, Luca
Marracino, Federico
Realini, Natalia
Lenzi, Paola
Martinello, Katiuscia
Bovier, Tiziana Francesca
Bichell, Terry Jo
Scarselli, Pamela
Di Cicco, Clotilde
Bowman, Aaron B.
Digilio, Filomena A.
Fucile, Sergio
Fornai, Francesco
Armirotti, Andrea
Parlato, Rosanna
Di Pardo, Alba
Maglione, Vittorio
MOLECULAR THERAPY, 2023, 31 (01) : 282 - 299
[2] Sphingosine-1-Phosphate Lyase (SGPL1) Deficiency Is Associated with Mitochondrial Dysfunction
Maharaj, Avinaash
Bradshaw, Teisha
Williams, Jack
Guran, Tulay
Braslavsky, Debora
Bruegger, Britta
Metherell, Lou
Prasad, Rathi
HORMONE RESEARCH IN PAEDIATRICS, 2018, 90 : 78 - 78
[3] Sphingosine-1-phosphate lyase (SGPL1) deficiency is associated with mitochondrial dysfunction
Maharaj, A.
Williams, J.
Bradshaw, T.
Guran, T.
Braslavsky, D.
Casas, J.
Chan, L. F.
Metherell, L. A.
Prasad, R.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2020, 202
[4] SGPL1 (sphingosine phosphate lyase 1) modulates neuronal autophagy via phosphatidylethanolamine production
Mitroi, Daniel N.
Karunakaran, Indulekha
Graeler, Markus
Saba, Julie D.
Ehninger, Dan
Dolores Ledesma, Maria
van Echten-Deckert, Gerhild
AUTOPHAGY, 2017, 13 (05) : 885 - 899
[5] A rare cause of nephrotic syndrome - sphingosine-1-phosphate lyase (SGPL1) deficiency: 2 cases
Spizzirri, Ana Paula
Cobenas, Carlos Jose
Suarez, Angela del Carmen
PEDIATRIC NEPHROLOGY, 2023, 38 (01) : 307 - 308
[6] A rare cause of nephrotic syndrome – sphingosine-1-phosphate lyase (SGPL1) deficiency: 2 cases
Ana Paula Spizzirri
Carlos José Cobeñas
Angela del Carmen Suarez
Pediatric Nephrology, 2023, 38 : 307 - 308
[7] Deficiency of the sphingosine-1-phosphate lyase SGPL1 is associated with congenital nephrotic syndrome and congenital adrenal calcifications
Janecke, Andreas R.
Xu, Ruijuan
Steichen-Gersdorf, Elisabeth
Waldegger, Siegfried
Entenmann, Andreas
Giner, Thomas
Krainer, Iris
Huber, Lukas A.
Hess, Michael W.
Frishberg, Yaacov
Barash, Hila
Tzur, Shay
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Zehavi, Tania
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HUMAN MUTATION, 2017, 38 (04) : 365 - 372
[8] Targeting sphingosine-1-phosphate lyase is neuroprotective in a neuron model of Huntington's disease
Furr-Stimming, Erin
Tsvetkov, Andrey
NEUROLOGY, 2017, 88
[9] A rare cause of nephrotic syndrome—sphingosine-1-phosphate lyase (SGPL1) deficiency: 6 cases and a review of the literature
Tugba Tastemel Ozturk
Nur Canpolat
Seha Saygili
Umut Selda Bayrakci
Oguz Soylemezoglu
Fatih Ozaltin
Rezan Topaloglu
Pediatric Nephrology, 2023, 38 : 711 - 719
[10] Inhibiting sphingosine-1-phosphate lyase as a possible therapy in Huntington's disease
Stimming, E. Furr
Manchon, J. F.
Tsvetkov, A.
MOVEMENT DISORDERS, 2017, 32

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