A review of the potential therapeutic role of statins in the treatment of Alzheimer's disease: current research and opinion

被引：0
|
作者：
Sanchez-Ferro, Alvaro [1 ,2 ,3 ,4 ]
Benito-Leon, Julian [1 ,2 ,3 ]
Mitchell, Alex J. [5 ,6 ]
Bermejo-Pareja, Felix [1 ,2 ,3 ]
机构：
[1] Univ Hosp 12 Octubre, Dept Neurol, Madrid, Spain
[2] Univ Complutense, Dept Med, E-28040 Madrid, Spain
[3] Ctr Invest Biomed Red Enfermedades Neurodegenerat, Madrid, Spain
[4] Inst Salud Carlos III, Madrid, Spain
[5] Leicestershire Partnership NHS Trust, Dept Psychooncol, Leicester, Leics, England
[6] Univ Leicester, Leicester, Leics, England
来源：
NEUROPSYCHIATRIC DISEASE AND TREATMENT | 2013年 / 9卷
关键词：
animal models; epidemiology; HMGCoA-inhibitors; clinical trials; prevention; cognitive function; RANDOMIZED CONTROLLED-TRIAL; APOLIPOPROTEIN-E GENOTYPE; COGNITIVE FUNCTION; CHOLESTEROL LEVEL; BLOOD-PRESSURE; SERUM-CHOLESTEROL; REDUCED RISK; LOWERING TREATMENT; INCIDENT DEMENTIA; PLASMA-LIPIDS;
D O I：
10.2147/NDT.529105
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Alzheimer's disease is one of the most prevalent neurodegenerative disorders. However, there is no current treatment, which definitively influences disease progression over a sustained period. Numerous studies linking an increase in serum cholesterol, mainly during midlife, with the pathogenic process of Alzheimer's disease have been published. Therefore, the role of statins as a therapy in this disorder may be of great interest. The aim of the present review is to summarize of the role of statins in the treatment of Alzheimer's disease.
引用
收藏
页码：55 / 63
页数：9
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