Cytotoxic Prodigiosin Family Pigments from Pseudoalteromonas sp 1020R Isolated from the Pacific Coast of Japan

被引:31
|
作者
Wang, Yi [1 ]
Nakajima, Aya [1 ]
Hosokawa, Kakushi [1 ]
Soliev, Azamjon B. [1 ]
Osaka, Issey [2 ]
Arakawa, Ryuichi [2 ]
Enomoto, Keiichi [1 ]
机构
[1] Kochi Univ Technol, Dept Environm Syst Engn, Kami, Kochi 7828502, Japan
[2] Kansai Univ, Fac Chem Mat & Bioengn, Dept Chem & Mat Engn, Suita, Osaka 5648680, Japan
基金
日本科学技术振兴机构;
关键词
Pseudoalteromonas; prodigiosin; cytotoxicity; apoptosis; MARINE BACTERIUM; PRODIGININES; RUBRA; RED;
D O I
10.1271/bbb.110984
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Pseudoalteromonas sp. 1020R, isolated from the Pacific coast of Japan, produces prodigiosin family pigments. Structural analysis indicated that these are prodigiosin (2-methyl-3-pentyl-prodiginine) and three other prodigiosin congeners which differ only in the lengths of the alkyl side chains. These compounds exhibited different extents of cytotoxicity against U937 leukemia cells, and cell death was accompanied by typical features of apoptosis.
引用
收藏
页码:1229 / 1232
页数:4
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