NADPH oxidase subunit 4 (Nox4) is not the only responsible isoform for generation of ROS and DNA damage in the kidney during Ang II-treatment in vivo

被引：0
|
作者：
Zimnol, A. [1 ,2 ]
Schupp, N. [1 ,2 ]
机构：
[1] Univ Dusseldorf, Inst Toxicol, Dusseldorf, Germany
[2] Univ Wurzburg, Inst Pharmacol & Toxicol, Wurzburg, Germany
来源：
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | 2015年 / 388卷
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D O I：
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中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
262
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页码：S66 / S66
页数：1
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  • [1] Angiotensin II induces DNA damage via AT1 receptor and NADPH oxidase isoform Nox4
    Fazeli, Gholamreza
    Stopper, Helga
    Schinzel, Reinhard
    Ni, Chih-Wen
    Jo, Hanjoong
    Schupp, Nicole
    [J]. MUTAGENESIS, 2012, 27 (06) : 673 - 681
  • [2] Transcriptional regulation of the Nox4 isoform subunit of NADPH oxidase in endothelial cells
    Pitsiouni, M
    Brewer, A
    Shah, AM
    Gove, CD
    [J]. HEART, 2004, 90 (12)
  • [3] The emerging role of ROS-generating NADPH oxidase NOX4 in DNA-damage responses
    Weyemi, Urbain
    Dupuy, Corinne
    [J]. MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH, 2012, 751 (02) : 77 - 81
  • [4] First in Class, Potent, and Orally Bioavailable NADPH Oxidase Isoform 4 (Nox4) Inhibitors for the Treatment of Idiopathic Pulmonary Fibrosis
    Laleu, Benoit
    Gaggini, Francesca
    Orchard, Mike
    Fioraso-Cartier, Laetitia
    Cagnon, Laurene
    Houngninou-Molango, Sophie
    Gradia, Angelo
    Duboux, Guillaume
    Merlot, Cedric
    Heitz, Freddy
    Szyndralewiez, Cedric
    Page, Patrick
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2010, 53 (21) : 7715 - 7730
  • [5] ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence
    Weyemi, U.
    Lagente-Chevallier, O.
    Boufraqech, M.
    Prenois, F.
    Courtin, F.
    Caillou, B.
    Talbot, M.
    Dardalhon, M.
    Al Ghuzlan, A.
    Bidart, J-M
    Schlumberger, M.
    Dupuy, C.
    [J]. ONCOGENE, 2012, 31 (09) : 1117 - 1129
  • [6] ROS-generating NADPH oxidase NOX4 is a critical mediator in oncogenic H-Ras-induced DNA damage and subsequent senescence
    U Weyemi
    O Lagente-Chevallier
    M Boufraqech
    F Prenois
    F Courtin
    B Caillou
    M Talbot
    M Dardalhon
    A Al Ghuzlan
    J-M Bidart
    M Schlumberger
    C Dupuy
    [J]. Oncogene, 2012, 31 : 1117 - 1129
  • [7] Increased NADPH-oxidase activity and nox4 expression during chronic hypertension is associated with enhanced cerebral vasodilatation to NADPH in vivo
    Paravicini, TM
    Chrissobolis, S
    Drummond, GR
    Sobey, CG
    [J]. STROKE, 2004, 35 (02) : 584 - 589
  • [8] The NADPH oxidase NOX4 induces the DNA damage response by activating the ATM-CHK2-p53 pathway
    Kracun, D.
    Kanchev, I.
    Schmitt, M.
    Goerlach, A.
    [J]. ACTA PHYSIOLOGICA, 2014, 210 : 58 - 58
  • [9] PHARMACOLOGICAL INHIBITION OF NADPH OXIDASE (NOX1/NOX4) AMELIORATES ALBUMINURIA AND KIDNEY DAMAGE IN STREPTOZOTOCIN INDUCED DIABETIC APOE KO MICE
    Jha, J.
    Gray, S.
    Page, P.
    Szyndralewiez, C.
    Heitz, F.
    Wiesel, P.
    Cooper, M.
    Jandeleit-Dahm, K.
    [J]. NEPHROLOGY, 2012, 17 : 72 - 72
  • [10] Role of the NADPH oxidase subunit Nox4 in generation of reactive oxygen species and growth arrest of vascular smooth muscle cells in atherosclerosis.
    Xu, SP
    Miller, FJ
    [J]. JOURNAL OF INVESTIGATIVE MEDICINE, 2005, 53 (02) : S363 - S363
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