Synthesis of 6′-deoxy-6′-fluorosucrose

被引：7
|
作者：
Gaddam, Vikram [1 ]
Harmata, Michael [1 ]
机构：
[1] Univ Missouri, Dept Chem, Columbia, MO 65211 USA
来源：
CARBOHYDRATE RESEARCH | 2013年 / 369卷
关键词：
Fluorination; Fluorosucrose; Fluorosugar; Kryptofix [2.2.2; POSITRON-EMISSION-TOMOGRAPHY; SUCROSE TRANSPORTER; ORGANIC-COMPOUNDS; CHEMISTRY; FLUORINE; SUCROCHEMISTRY; COMPLEXES; SUGAR;
D O I：
10.1016/j.carres.2012.12.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A facile synthesis of 6'-deoxy-6'-fluorosucrose has been developed. The title compound is available in six linear steps in 44% overall yield from commercially available sucrose. The synthesis involves rapid and convenient fluorination and deprotection conditions. This procedure would be very useful for the incorporation of radioactive [F-18]. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：38 / 41
页数：4
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