Surface Glycoproteins of an African Henipavirus Induce Syncytium Formation in a Cell Line Derived from an African Fruit Bat, Hypsignathus monstrosus

被引：19

作者：

Krueger, Nadine ^{[1
]}

Hoffmann, Markus ^{[1
]}

Weis, Michael ^{[2
]}

Drexler, Jan Felix ^{[3
]}

Mueller, Marcel Alexander ^{[3
]}

Winter, Christine ^{[1
]}

Corman, Victor Max ^{[3
]}

Guetzkow, Tim ^{[1
]}

Drosten, Christian ^{[3
]}

Maisner, Andrea ^{[2
]}

Herrler, Georg ^{[1
]}

机构：

[1] Univ Vet Med Hannover, Inst Virol, Hannover, Germany

[2] Univ Marburg, Inst Virol, D-35032 Marburg, Germany

[3] Univ Bonn, Med Centrer, Inst Virol, Bonn, Germany

来源：

JOURNAL OF VIROLOGY | 2013年 / 87卷 / 24期

关键词：

INFECTIOUS-BRONCHITIS VIRUS; NIPAH VIRUS; SPIKE PROTEIN; HENDRA VIRUS; RECEPTOR; ENTRY; MOTIF;

D O I：

10.1128/JVI.02458-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Serological screening and detection of genomic RNA indicates that members of the genus Henipavirus are present not only in Southeast Asia but also in African fruit bats. We demonstrate that the surface glycoproteins F and G of an African henipavirus (M74) induce syncytium formation in a kidney cell line derived from an African fruit bat, Hypsignathus monstrosus. Despite a less broad cell tropism, the M74 glycoproteins show functional similarities to glycoproteins of Nipah virus.

引用

页码：13889 / 13891

页数：3

共 8 条

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