Tumor-infiltrating lymphocytes, breast cancer subtypes and therapeutic efficacy

被引：88
|
作者：
Loi, Sherene [1 ,2 ]
机构：
[1] Peter MacCallum Canc Ctr, Translat Breast Canc Genom Lab, Canc Therapeut Program, East Melbourne, Vic, Australia
[2] Univ Melbourne, Sir Peter MacCallum Dept Oncol, Parkville, Vic 3052, Australia
来源：
ONCOIMMUNOLOGY | 2013年 / 2卷 / 07期
关键词：
breast cancer; immunotherapies; biomarkers; tumor infiltrating lymphocytes; prognosis; trastuzumab efficacy; MICROENVIRONMENT; ADJUVANT;
D O I：
10.4161/onci.24720
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
By analyzing over 2000 samples from a randomized clinical trial, we have recently associated high levels of tumor-infiltrating lymphocytes with an excellent prognosis among triple negative breast cancer patients as well with improved clinical responses to immunogenic chemotherapy among patients bearing HER2 over-expression. These findings suggest that immunomodulation could represent a new approach to treat these aggressive breast cancer subtypes.
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页数：3
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