Precision and accuracy of clinical quantification of myocardial blood flow by dynamic PET: A technical perspective

被引:52
|
作者
Moody, Jonathan B. [1 ]
Lee, Benjamin C. [1 ]
Corbett, James R. [2 ,3 ]
Ficaro, Edward P. [1 ,2 ]
Murthy, Venkatesh L. [2 ,3 ]
机构
[1] INVIA Med Imaging Solut, Ann Arbor, MI USA
[2] Univ Michigan, Div Nucl Med, Dept Radiol, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Dept Internal Med, Div Cardiovasc Med, Ann Arbor, MI 48109 USA
关键词
Myocardial blood flow; Myocardial flow reserve; Cardiac PET/CT; Rubidium-82; TIME-OF-FLIGHT; POSITRON-EMISSION-TOMOGRAPHY; CORONARY-ARTERY-DISEASE; COUNT-RATE; RB-82; PET; ITERATIVE RECONSTRUCTION; PERFORMANCE EVALUATION; IMAGE-RECONSTRUCTION; RESERVE MEASUREMENTS; PROGNOSTIC VALUE;
D O I
10.1007/s12350-015-0100-0
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A number of exciting advances in PET/CT technology and improvements in methodology have recently converged to enhance the feasibility of routine clinical quantification of myocardial blood flow and flow reserve. Recent promising clinical results are pointing toward an important role for myocardial blood flow in the care of patients. Absolute blood flow quantification can be a powerful clinical tool, but its utility will depend on maintaining precision and accuracy in the face of numerous potential sources of methodological errors. Here we review recent data and highlight the impact of PET instrumentation, image reconstruction, and quantification methods, and we emphasize Rb-82 cardiac PET which currently has the widest clinical application. It will be apparent that more data are needed, particularly in relation to newer PET technologies, as well as clinical standardization of PET protocols and methods. We provide recommendations for the methodological factors considered here. At present, myocardial flow reserve appears to be remarkably robust to various methodological errors; however, with greater attention to and more detailed understanding of these sources of error, the clinical benefits of stress-only blood flow measurement may eventually be more fully realized.
引用
收藏
页码:935 / 951
页数:17
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