An Acid-Catalysed Hydroamination Approach to Isoindolines

被引：10
|
作者：
Henderson, Laura [1 ]
Knight, David W. [1 ]
Williams, Andrew C. [2 ]
机构：
[1] Cardiff Univ, Main Coll, Sch Chem, Cardiff CF10 3AT, S Glam, Wales
[2] Eli Lilly & Co Ltd, Lilly Res Ctr, Windlesham GU20 6PH, Surrey, England
来源：
SYNLETT | 2012年 / 11期
基金：
英国工程与自然科学研究理事会;
关键词：
cyclisation; sulfonamides; heterocycles; hydroamination; isoindolines; ALKYNES; ALKENES;
D O I：
10.1055/s-0031-1291155
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Acid-catalysed intramolecular hydroaminations of 2-alkenylarylethylamine derivatives lead smoothly to isoindolines via benzylic carbenium ion generation.
引用
收藏
页码：1667 / 1669
页数：3
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