Stereospecific preparation of (Z)-α-fluorostilbenes via a kinetically controlled palladium-catalyzed cross-coupling reaction of high E/Z ratio 1-bromo-1-fluorostyrenes and aryl stannanes

被引：25

作者：

Xu, JJ ^{[1
]}

Burton, DJ ^{[1
]}

机构：

[1] Univ Iowa, Dept Chem, Iowa City, IA 52242 USA

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 15期

基金：

美国国家科学基金会;

关键词：

fluorostilbenes; palladium-catalyzed cross-coupling; stereospecific; isomerization; bromofluoroalkenes; kinetic separation;

D O I：

10.1016/S0040-4039(02)00357-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

High E/Z ratios were obtained for 1-bromo-1-fluorostyrenes by isomerization from the original E/Z ratios of approximately 1:1. The palladium-catalyzed cross-coupling reaction of high E/Z ratio 1-bromo-1-fluorostyrenes with aryl stannanes gives (Z)-alpha-fluorostilbenes stereospecifically in good yields. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2877 / 2879

页数：3

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