The responses of the thermospheric density and ionospheric foF2 to the intense magnetic storms event on 17-20 April were analyzed by using data from CHAMP/STAR and ionosonde stations respectively, and NRLMSISE-00 and IRI-2007 models were used to simulate. The models can capture the tendency of changes, especially under quiet or moderate geomagnetic conditions, but are less accurate under geomagnetic storms. The thermospheric density is sensitive to the EUV emission and geomagnetic activity, and double-peak structure appeared in the dayside. On 19 April dayside, TADs traveled toward the equator with phase speeds of the order of 300-750 m/s, interfered near the equator to produce a total density perturbation of 25%, and then passed through each other and into the opposite hemisphere. For ionospheric foF2, there are non-symmetric hemispheres' features during the intense geomagnetic activities. In details, middle latitudes in the north and high latitudes in both hemispheres are negative ionospheric storms, and the maximum amplitudes of delta foF2 is about 60%, but the amplitudes decrease from the higher to lower latitudes in the Southern Hemisphere. Meanwhile, the equatorial station shows positive phase, and the maximum value is about 100%. Finally, the mechanisms for these features will be discussed in this study. Published by Elsevier Ltd. on behalf of COSPAR.