How antibodies act as natural adjuvants

被引：42
|
作者：
Getahun, A [1 ]
Heyman, B [1 ]
机构：
[1] Uppsala Univ, Dept Genet & Pathol, SE-75185 Uppsala, Sweden
来源：
IMMUNOLOGY LETTERS | 2006年 / 104卷 / 1-2期
关键词：
Fc-receptors; complement; antibody response; immune complexes; T helper cells; IgM; IgG; IgE; review;
D O I：
10.1016/j.imlet.2005.11.005
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Antibodies can act like adjuvants. They can potently enhance the antibody response, and in the case of I-G and IgE also the T cell response, to the very antigen they are specific for. In this review we will discuss the recent advances made in our understanding of the underlying mechanisms of antibody-mediated feedback enhancement. The immuno-stimulatory properties of IgM, IgG1, IgG2a, IgG2b, IgG3 and IgE will be reviewed in relationship to the complement system and Fc receptors and the physiological relevance will be discussed. (C) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码：38 / 45
页数：8
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