Retinoic acid induces adhesion and migration in NB4 cells through Pyk2 signaling

被引：9

作者：

Ovcharenko, Adelina ^{[1
]}

Granot, Galit ^{[1
]}

Shpilberg, Ofer ^{[1
,2
]}

Raanani, Pia ^{[1
,2
]}

机构：

[1] Tel Aviv Univ, Felsenstein Med Res Ctr, Petah Tiqwa, Israel

[2] Tel Aviv Univ, Inst Hematol, Beilinson Hosp, Sackler Sch Med, Petah Tiqwa, Israel

来源：

LEUKEMIA RESEARCH | 2013年 / 37卷 / 08期

关键词：

Acute promyelocytic leukemia; Extramedullary disease; ATRA; Pyk2; Adhesion; Migration; ACUTE PROMYELOCYTIC LEUKEMIA; TYROSINE PHOSPHORYLATION; POSITIVE-FEEDBACK; SEALING ZONE; C/EBP-BETA; LINE NB4; PAXILLIN; INTEGRIN; KINASE; DIFFERENTIATION;

D O I：

10.1016/j.leukres.2013.03.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Since the introduction of all-trans-retinoic acid (ATRA) treatment for acute promyelocytic leukemia (APL) there has been increasing concern about extramedullary disease (EMD) progression despite favorable response in the bone marrow. We postulated that ATRA treatment enhances migration and adhesion abilities possibly enabling APL cells to inhabit extramedullary sites. We revealed an increase in adhesion, migration and invasion capabilities of NB4 cells following ATRA treatment. ATRA induced upregulation of Pyk2 mRNA, protein and phosphorylation levels and enhanced Pyk2 interaction with paxillin and vinculin. Pyk2 inhibition resulted in a reduction of NB4 cell adhesion and migration following ATRA treatment. These results indicate that in vitro Pyk2 might function to regulate cell adhesion and motility following ATRA treatment and its upregulated expression may contribute to EMD development in APL patients. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：956 / 962

页数：7

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