The Investigation of the Neopluramycin - DNA System by UV-visible Spectroscopy

被引：0
|
作者：
Vijan, Loredana Elena [1 ]
机构：
[1] Univ Pitesti, Pitesti 110040, Romania
来源：
REVISTA DE CHIMIE | 2008年 / 59卷 / 09期
关键词：
neopluramycin; calf thymus DNA; self-association; UV-visible spectroscopy;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The self-association of neopluramycin and the binding of this drug to calf thymus DNA were investigated by using UV-visible spectroscopy. This classical pluramycin antibiotic self-associates in 1:1 ethanol - water mixture. Starting from a simple dimerization model, the molar absorption coefficient of monomer, the molar absorption coefficient of dimer and the dimerization constant were determined. The binding constant of neopluramycin to DNA was determined using Wolfe and Scatchard methods.
引用
收藏
页码：960 / 962
页数：3
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