Effect of maternal and paternal age on pregnancy and miscarriage rates after intrauterine insemination

被引：106

作者：

Belloc, Stephanie ^{[1
,2
,3
]}

Cohen-Bacrie, Paul ^{[1
,2
,3
]}

Benkhalifa, Moncef ^{[1
,4
]}

Cohen-Bacrie, Martine ^{[1
]}

De Mouzon, Jacques ^{[5
]}

Hazout, Andre ^{[2
]}

Menezo, Yves ^{[1
,2
,3
,4
]}

机构：

[1] Lab Eylau, F-75116 Paris, France

[2] Unite AMP Eylau La Muette, F-75116 Paris, France

[3] Unite AMP Eylau Cherest, F-92200 Neuilly Sur Seine, France

[4] ATL, F-78300 La Verriere, France

[5] INSERM, Unite 822, F-94276 Le Kremlin Bicetre, France

来源：

REPRODUCTIVE BIOMEDICINE ONLINE | 2008年 / 17卷 / 03期

关键词：

IUI; maternal age; miscarriage; paternal age;

D O I：

10.1016/S1472-6483(10)60223-4

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

More than 17.000 intrauterine insemination (IUI) cycles were analysed retrospectively with respect to outcome according to differing aetiologies of infertility. The quantity and mobility motility of spermatozoa in the final preparation used for insemination had a positive effect on the outcome, as classically observed in the past. It was found that advanced maternal age had a negative effect oil the pregnancy rate and was associated with increased miscarriage rate. More interestingly. an exactly parallel effect was found for paternal age. The impact of increased age on necrospermia and sperm DNA structure is discussed as a probable direct cause of this paternal effect.

引用

页码：392 / 397

页数：6

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