Low-hanging fruit: targeting Brdt in the testes

被引：9
|
作者：
Bryant, Jessica M.
Berger, Shelley L. [1 ]
机构：
[1] Univ Penn, Epigenet Program, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA
来源：
EMBO JOURNAL | 2012年 / 31卷 / 19期
关键词：
BROMODOMAIN; CHROMATIN; INHIBITION;
D O I：
10.1038/emboj.2012.259
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In this issue of The EMBO Journal, Gaucher et al (2012) demonstrate that Brdt, a testes-specific member of the BET family of double bromodomain proteins, is intricately involved in the transcriptional regulation and genome reorganization required for the production of viable, fertile sperm. These findings are complimented by a recent publication in Cell (Matzuk et al, 2012) where JQ1, a small molecule BET inhibitor, is effective as a male contraceptive in mice. Both studies establish Brdt as an integral factor in sperm development.
引用
收藏
页码：3788 / 3789
页数：2
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