Comparative study of catalytic (DNA-hydrolyzing) and cytotoxic properties of anti-DNA autoantibodies

被引：4
|
作者：
Suchkov, SV [1 ]
机构：
[1] Moscow Reg Res & Clin Inst, Clin Immunol Lab, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2001年 / 131卷 / 04期
关键词：
DNA abzymes; anti-DNA autoantibodies; cytotoxicity; autoimmune mice; systemic lupus erythematosus;
D O I：
10.1023/A:1017904219726
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
DNA-hydrolyzing and cytotoxic properties of anti-DNA autoantibodies isolated from patients with systemic autoimmune diseases and from autoimmune MRL-1pr/1pr, SJL/J, and (NZBx NZW)F-1 mice were studied. Cytotoxic and catalytic properties of these antibodies correlated. A relationship between the stage of systemic lupus erythematosus and catalytic and cytotoxic properties of DNA abzymes was revealed. Of all studied cells, L929 cells were most sensitive were most sensitive to in vitro effect of antibodies. Treatment of target cells with anti-DNA autoantibodies with cytotoxic properties induced internucleosomal DNA fragmentation, which is characteristic of apoptosis.
引用
收藏
页码：353 / 355
页数：3
相关论文
共 50 条
  • [1] Comparative Study of Catalytic (DNA-Hydrolyzing) and Cytotoxic Properties of Anti-DNA Autoantibodies
    S. V. Suchkov
    [J]. Bulletin of Experimental Biology and Medicine, 2001, 131 : 353 - 355
  • [2] DNA-HYDROLYZING AUTOANTIBODIES
    GABIBOV, AG
    GOLOLOBOV, GV
    MAKAREVICH, OI
    SCHOUROV, DV
    CHERNOVA, EA
    YADAV, RP
    [J]. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 1994, 47 (2-3) : 293 - 303
  • [3] Disease association and cytotoxic effects of DNA-hydrolyzing autoantibodies
    Gabibov, AG
    Kozyr, AV
    Kolesnikov, AV
    [J]. CATALYTIC ANTIBODIES, 2000, 77 : 130 - 156
  • [4] DNA-HYDROLYZING AUTOANTIBODIES IN AUTOIMMUNE PATHOLOGIES
    SCHOUROV, DV
    GOLOLOBOV, GV
    MAKAREVICH, OI
    YADAV, RP
    CHERNOVA, EA
    NEVINSKY, GA
    PROKAEVA, TB
    ALEKBEROVA, ZS
    GABIBOV, AG
    [J]. ENZYME ENGINEERING XII, 1995, 750 : 255 - 264
  • [5] Anti-DNA antibodies in the blood of patients with schizophrenia possess DNA-hydrolyzing activity
    Ermakov, E.
    Smirnova, L.
    Sinyanskii, L.
    Dobrygina, D.
    Semke, A.
    Nevinsky, G.
    Buneva, V.
    Ivanova, S.
    [J]. EUROPEAN PSYCHIATRY, 2016, 33 : S247 - S248
  • [6] Anti-DNA and autoantibodies
    Pisetsky, DS
    [J]. CURRENT OPINION IN RHEUMATOLOGY, 2000, 12 (05) : 364 - 368
  • [7] Human catalytic RNA- and DNA-hydrolyzing antibodies
    Nevinsky, GA
    Buneva, VN
    [J]. JOURNAL OF IMMUNOLOGICAL METHODS, 2002, 269 (1-2) : 235 - 249
  • [8] Autoantibodies to nuclear antigensCorrelation between cytotoxicity and DNA-hydrolyzing activity
    A. V. Kozyr
    A. V. Kolesnikov
    N. A. Zelenova
    L. P. Sashchenko
    S. V. Mikhalap
    M. E. Bulina
    A. N. Ignatova
    P. V. Favorov
    A. G. Gabibov
    [J]. Applied Biochemistry and Biotechnology, 2000, 83 : 255 - 269
  • [9] ORIGINS OF ANTI-DNA AUTOANTIBODIES
    SCHWARTZ, RS
    STOLLAR, BD
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1985, 75 (02): : 321 - 327
  • [10] Intricacies of anti-DNA autoantibodies
    Radic, MZ
    Weigert, M
    [J]. JOURNAL OF IMMUNOLOGY, 2004, 172 (06): : 3367 - 3367
12345