Genes encoding ACE2, TMPRSS2 and related proteins mediating SARS-CoV-2 viral entry are upregulated with age in human cardiomyocytes

被引：15

作者：

Robinson, Emma L. ^{[1
,2
]}

Alkass, Kanar ^{[3
]}

Bergmann, Olaf ^{[4
,5
]}

Maguire, Janet J. ^{[6
]}

Roderick, H. Llewelyn ^{[2
,7
]}

Davenport, Anthony P. ^{[6
]}

机构：

[1] Maastricht Univ, Cardiovasc Res Inst Maastricht CARIM, Dept Cardiol, Maastricht, Netherlands

[2] Katholieke Univ Leuven, Dept Cardiovasc Sci, Lab Expt Cardiol, Campus Gasthuisberg,Herestr 49, B-3000 Leuven, Belgium

[3] Karolinska Inst, BioClinicum, Oncol & Pathol, Natl Board Forens Med, SE-17177 Stockholm, Sweden

[4] Tech Univ Dresden, Ctr Regenerat Therapies Dresden, Fetscherstr 105, D-01307 Dresden, Germany

[5] Karolinska Inst, Biomedicum, Cell & Mol Biol, SE-17177 Stockholm, Sweden

[6] Univ Cambridge, Addenbrookes Hosp, Expt Med & Immunotherapeut, Cambridge, England

[7] Univ Oslo, KG Jebsen Ctr Cardiac Res, N-3000 Oslo, Norway

来源：

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 2020年 / 147卷

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会; 瑞典研究理事会;

关键词：

Human cardiomyocytes; RNA-sequencing; Angiotensin; Apelin; Bradykinin; SARS-CoV-2; COVID-19;

D O I：

10.1016/j.yjmcc.2020.08.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：88 / 91

页数：4

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