Indoor Volatile Organic Compounds and Chemical Sensitivity Reactions

被引:20
|
作者
Win-Shwe, Tin-Tin [1 ]
Fujimaki, Hidekazu [2 ]
Arashidani, Keiichi [3 ]
Kunugita, Naoki [4 ]
机构
[1] Natl Inst Environm Studies, Ctr Environm Hlth Sci, Tsukuba, Ibaraki 3058506, Japan
[2] Natl Inst Environm Studies, Ctr Environm Risk Res, Tsukuba, Ibaraki 3058506, Japan
[3] Univ Occupat & Environm Hlth, Yahatanishi Ku, Kitakyushu, Fukuoka 8078555, Japan
[4] Natl Inst Publ Hlth, Dept Environm Hlth, Wako, Saitama 3510197, Japan
关键词
TYROSINE-HYDROXYLASE EXPRESSION; MEDIATED LOCOMOTOR-ACTIVITY; NERVE GROWTH-FACTOR; LONG-TERM EXPOSURE; FORMALDEHYDE INCREASES; RESTRAINT STRESS; OLFACTORY-BULB; LEVEL; MODEL; MOUSE;
D O I
10.1155/2013/623812
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Studies of unexplained symptoms observed in chemically sensitive subjects have increased the awareness of the relationship between neurological and immunological diseases due to exposure to volatile organic compounds (VOCs). However, there is no direct evidence that links exposure to low doses of VOCs and neurological and immunological dysfunction. We review animal model data to clarify the role of VOCs in neuroimmune interactions and discuss our recent studies that show a relationship between chronic exposure of C3H mice to low levels of formaldehyde and the induction of neural and immune dysfunction. We also consider the possible mechanisms by which VOC exposure can induce the symptoms presenting in patients with a multiple chemical sensitivity.
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页数:8
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