A highly enantioselective synthesis of (R)-salmeterol using a chiral auxiliary

被引：3

作者：

Jiang, Lijue ^{[1
]}

Lin, Chenggang ^{[1
]}

Qiu, Yinhua ^{[1
]}

Quan, Xu ^{[1
]}

Zhu, Jing ^{[1
]}

Shi, Haijian ^{[1
]}

机构：

[1] Nanjing Tech Univ, Coll Chem Engn, Nanjing 210009, Jiangsu, Peoples R China

来源：

JOURNAL OF CHEMICAL RESEARCH | 2016年 / 09期

关键词：

(R)-salmeterol; chiral auxiliary; enantioselective; ASYMMETRIC HENRY REACTION;

D O I：

10.3184/174751916X14719559894647

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A facile strategy for enantioselective synthesis of (R)-salmeterol is described via a chiral auxiliary starting from 2-bromo-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl) ethanone through four or five steps. The product was obtained in good purity, enantiomeric excess and yield.

引用

页码：564 / 566

页数：3

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