Redox-dependent and independent effects of thioredoxin interacting protein

被引：26
|
作者：
Cao, Xiankun [3 ]
He, Wenxin [3 ]
Pang, Yichuan [4 ]
Cao, Yu [1 ,2 ]
Qin, An [3 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Orthopaed, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Inst Precis Med, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China
[3] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Shanghai Key Lab Orthoped Implants,Dept Orthopaed, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China
[4] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 10,Dept Oral Surg, Natl Clin Res Ctr Stomatol,Shanghai Key Lab Stoma, Shanghai 200011, Peoples R China
来源：
BIOLOGICAL CHEMISTRY | 2020年 / 401卷 / 11期
基金：
中国国家自然科学基金;
关键词：
apoptosis; inflammation; metabolism; redox; tumourigenesis; TXNIP; NF-KAPPA-B; UP-REGULATED PROTEIN-1; NLRP3 INFLAMMASOME ACTIVATION; HUMAN MITOCHONDRIAL THIOREDOXIN; CARBOHYDRATE RESPONSE ELEMENT; BETA-CELL DEATH; OXIDATIVE STRESS; REACTIVE OXYGEN; BINDING-PROTEIN; CANCER-CELLS;
D O I：
10.1515/hsz-2020-0181
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Thioredoxin interacting protein (TXNIP) is an important physiological inhibitor of the thioredoxin (TXN) redox system in cells. Regulation of TXNIP expression and/or activity not only plays an important role in redox regulation but also exerts redox-independent physiological effects that exhibit direct pathophysiological consequences including elevated inflammatory response, aberrant glucose metabolism, cellular senescence and apoptosis, cellular immunity, and tumorigenesis. This review provides a brief overview of the current knowledge concerning the redox-dependent and independent roles of TXNIP and its relevance to various disease states. The implications for the therapeutic targeting of TXNIP will also be discussed.
引用
收藏
页码：1215 / 1231
页数：17
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