Cyclophilins in Atherosclerosis: A New Therapeutic Target?

被引：0
|
作者：
Bukrinsky, Michael [1 ]
Orekhov, Alexander [2 ]
Ditiatkovski, Michael [3 ]
Sviridov, Dmitri [3 ]
机构：
[1] George Washington Univ, Sch Med & Hlth Sci, Dept Microbiol Immunol & Trop Med, Washington, DC 20052 USA
[2] Inst Atherosclerosis, Moscow, Russia
[3] Baker IDI Heart & Diabet Inst, Melbourne, Vic, Australia
来源：
CURRENT PHARMACEUTICAL DESIGN | 2013年 / 19卷 / 33期
关键词：
Extracellular cyclophilins; chemotaxis; inflammation; CD147; leukocytes; monocytes; MATRIX-METALLOPROTEINASE PRODUCTION; SMOOTH-MUSCLE-CELLS; MONOCYTE CHEMOATTRACTANT PROTEIN-1; CYCLOSPORINE-A; ENDOTHELIAL-CELLS; RHEUMATOID-ARTHRITIS; EXTRACELLULAR-MATRIX; LUNG INFLAMMATION; OXIDATIVE STRESS; GENE-EXPRESSION;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Atherosclerosis is a chronic disease with a significant inflammatory component. Recent studies indicate a role of extracellular cyclophilins as contributors to endothelial inflammation and pathogenesis of atherosclerosis. In this article, we review current literature on pro-inflammatory activities of extracellular cyclophilins and discuss possible approaches to selectively target this novel pro-inflammatory factor.
引用
收藏
页码：5904 / 5908
页数：5
相关论文
共 50 条
  • [1] The Notch pathway: a new therapeutic target in atherosclerosis?
    Rizzo, Paola
    Ferrari, Roberto
    [J]. EUROPEAN HEART JOURNAL SUPPLEMENTS, 2015, 17 (0A) : A74 - A76
  • [2] Regulatory T cells as a new therapeutic target for atherosclerosis
    Ou, Han-xiao
    Guo, Bing-bing
    Liu, Qi
    Li, Yu-kun
    Yang, Zhen
    Feng, Wen-jie
    Mo, Zhong-cheng
    [J]. ACTA PHARMACOLOGICA SINICA, 2018, 39 (08) : 1249 - 1258
  • [3] Regulatory T cells as a new therapeutic target for atherosclerosis
    Han-xiao Ou
    Bing-bing Guo
    Qi Liu
    Yu-kun Li
    Zhen Yang
    Wen-jie Feng
    Zhong-cheng Mo
    [J]. Acta Pharmacologica Sinica, 2018, 39 : 1249 - 1258
  • [4] Cyclooxygenase-2:: a new therapeutic target in atherosclerosis?
    Paramo, Jose A.
    Beloqui, Oscar
    Orbe, Josune
    [J]. MEDICINA CLINICA, 2006, 126 (20): : 782 - 786
  • [5] A new therapeutic target for atherosclerosis treatment: interview with Uday Saxena
    Quigley, E
    Saxena, U
    [J]. EXPERT OPINION ON THERAPEUTIC TARGETS, 2006, 10 (01) : 1 - 3
  • [6] Another therapeutic target for atherosclerosis
    Diker, Erdem
    [J]. TURK KARDIYOLOJI DERNEGI ARSIVI-ARCHIVES OF THE TURKISH SOCIETY OF CARDIOLOGY, 2015, 43 (04): : 415 - 415
  • [7] Inflammation as a Therapeutic Target in Atherosclerosis
    Nguyen, Mau T.
    Fernando, Sanuja
    Schwarz, Nisha
    Tan, Joanne T. M.
    Bursill, Christina A.
    Psaltis, Peter J.
    [J]. JOURNAL OF CLINICAL MEDICINE, 2019, 8 (08)
  • [8] The HDL receptor SR-BI: a new therapeutic target for atherosclerosis?
    Acton, SL
    Kozarsky, KF
    Rigotti, A
    [J]. MOLECULAR MEDICINE TODAY, 1999, 5 (12): : 518 - 524
  • [9] Epigenetic control of atherosclerosis via DNA methylation: A new therapeutic target?
    Gorabi, Armita Mahdavi
    Penson, Peter E.
    Banach, Maciej
    Motallebnezhad, Morteza
    Jamialahmadi, Tannaz
    Sahebkar, Amirhossein
    [J]. LIFE SCIENCES, 2020, 253
  • [10] The monocyte/macrophage as a therapeutic target in atherosclerosis
    Saha, Prakash
    Modarai, Bijan
    Humphries, Julia
    Mattock, Katherine
    Waltham, Matthew
    Burnand, Kevin G.
    Smith, Alberto
    [J]. CURRENT OPINION IN PHARMACOLOGY, 2009, 9 (02) : 109 - 118
12345