A new strategy for facile synthesis of tetrasubstituted pyridine derivatives

被引：8
|
作者：
Chen, Jun [1 ]
Ni, Hangcheng [1 ]
Chen, Wenteng [1 ]
Zhang, Guolin [1 ]
Yu, Yongping [1 ]
机构：
[1] Zhejiang Univ, Inst Mat Med, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China
来源：
TETRAHEDRON | 2013年 / 69卷 / 37期
基金：
中国国家自然科学基金;
关键词：
Pyridine; Azidoketone; Alkyne; Heterocycle; Cyclization; ALPHA-AZIDO KETONES; 1,3-DICARBONYL DIANIONS; EFFICIENT SYNTHESIS; CONDENSATION; ALDEHYDES; LIGATION; PYRROLES;
D O I：
10.1016/j.tet.2013.06.082
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A facile and efficient reaction of alpha-azidomethyl aryl ketones and dialkyl but-2-ynedioate offers a new strategy for the synthesis of tetrasubstituted pyridines in mild condition. This method tolerates a range of functionality and a possible mechanism is proposed. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：8069 / 8073
页数：5
相关论文
共 50 条
  • [1] NEW SYNTHESIS OF PYRIDINE DERIVATIVES
    ELOY, F
    DERYCKER.A
    [J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1970, 7 (05) : 1191 - &
  • [2] NEW SYNTHESIS OF PYRIDINE DERIVATIVES
    ELOY, F
    DERYCKER.A
    [J]. CHIMICA E L INDUSTRIA-MILAN, 1970, 5 (06): : 416 - &
  • [3] A Facile Synthesis of New 5-Substituted Pyridine-2-carboxamide Derivatives
    Dharman, Prabu
    Babu, Visagamoorthy
    Basha, K. Anver
    [J]. INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2021, 31 (02) : 191 - 194
  • [4] Facile and Efficient Synthesis of Tri- and Tetrasubstituted 7-Azabenzofuran Derivatives
    Fu, Chunsheng
    Li, Gaoyu
    Shen, Meng
    Zhang, Longxia
    Yu, Peng
    Wang, Dong
    [J]. ASIAN JOURNAL OF ORGANIC CHEMISTRY, 2020, 9 (05) : 749 - 752
  • [5] Synthesis of a New Series of Pyridine and Fused Pyridine Derivatives
    Al-Issa, Siham AbdulRahman
    [J]. MOLECULES, 2012, 17 (09): : 10902 - 10915
  • [6] Facile Synthesis and Herbicidal Activity of Novel Multisubstituted Pyridine Derivatives
    Ren, Qingyun
    Mo, Wenyan
    Gao, Ling
    He, Hongwu
    Gu, Yucheng
    [J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 2010, 47 (01) : 171 - 178
  • [7] Facile preparation of new unsymmetrical curcumin derivatives by solid-phase synthesis strategy
    Shao, Wei-Yan
    Cao, Ying-Nan
    Yu, Zhi-Wen
    Pan, Wen-Jie
    Qiu, Xu
    Bu, Xian-Zhang
    An, Lin-Kun
    Huang, Zhi-Shu
    Gu, Lian-Quan
    Chan, Albert S. C.
    [J]. TETRAHEDRON LETTERS, 2006, 47 (24) : 4085 - 4089
  • [8] SYNTHESIS AND ANTIMICROBIAL STUDIES OF NEW PYRIDINE DERIVATIVES
    Patel, N. B.
    Agravat, S. N.
    [J]. CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2009, 45 (11) : 1343 - 1353
  • [9] Synthesis and antimicrobial studies of new pyridine derivatives
    N. B. Patel
    S. N. Agravat
    [J]. Chemistry of Heterocyclic Compounds, 2009, 45 : 1343 - 1353
  • [10] HNMR SPECTRA OF INTERMEDIATE TETRASUBSTITUTED CYCLOPROPANE DERIVATIVES IN THE SYNTHESIS OF NEW PYRETHROIDS
    SANTORO, E
    BRAGATO, G
    PAPARATTO, G
    [J]. SPECTROSCOPY LETTERS, 1986, 19 (04) : 405 - 421
12345