Hybrid Magnetic Hydrogel: A Potential System for Controlled Drug Delivery by Means of Alternating Magnetic Fields

被引：65
|
作者：
Giani, Gabriele [1 ]
Fedi, Serena [1 ]
Barbucci, Rolando [1 ]
机构：
[1] Ctr Interuniv Sistemi Med Avanzati CRISMA, I-53034 Siena, Italy
来源：
POLYMERS | 2012年 / 4卷 / 02期
关键词：
magnetic nanoparticles; magnetic hydrogel; functionalization of nanoparticles; voltammetry analysis of nanoparticles; AFM analysis; IRON-OXIDE NANOPARTICLES; THIN-LAYERS; SILANE; RELEASE;
D O I：
10.3390/polym4021157
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Novel hybrid magnetic hydrogels have demonstrated their influence in several areas, particularly in biomedical science where these innovative materials are showing interesting applications for controlled drug delivery. A hybrid hydrogel with CoFe2O4 nanoparticles (NPs) as cross-linker agents of carboxymethylcellulose (CMC) polymer was obtained with the aim of testing it as a system for controlled drug release. The NPs were functionalized with (3-aminopropyl)-trimethoxysilane (APTMS) in order to introduce-NH2 groups on the surface. Infrared spectroscopy, XPS and electrochemical analysis were performed to quantify the amino coating. The presence of magnetic nanoparticles makes the system suitable for an application with magnetic stimulus. Preliminary studies performed with alternating magnetic fields indicate a release of the drug-like molecules previously loaded in the matrix.
引用
收藏
页码：1157 / 1169
页数：13
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