Methylobacterium extorquens AM1 produces a novel type of acyl-homoserine lactone with a double unsaturated side chain under methylotrophic growth conditions

被引：33

作者：

Penalver, CGN

Morin, D

Cantet, F

Saurel, O

Milon, A

Vorholt, JA

机构：

[1] INRA, CNRS, Lab Interact Plantes Microorganismes, F-31326 Castanet Tolosan, France

[2] Lab Biotechnol & Chim Marines, F-56321 Lorient, France

[3] Inst Pharmacol & Biol Struct, F-31077 Toulouse, France

来源：

FEBS LETTERS | 2006年 / 580卷 / 02期

关键词：

quorum sensing; methylotroph; C-1; metabolism;

D O I：

10.1016/j.febslet.2005.12.062

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Acyl-homoserine lactones (acyl-HSLs) have emerged as important regulatory molecules for many gram-negative bacteria. We have found that Methylobacterium extorquens AMI, a member of the pink-pigmented facultative methylotrophs commonly present on plant surfaces, produces several acyl-HSLs depending upon the carbon source. A novel HSL was discovered with a double unsaturated carbon chain (N-(tetradecenoyl)) (04:2) and characterized by MS and proton NMR. This long-chain acyl-HSL is synthesized by MlaI that also directs synthesis of C14:1-HSL. The Alphaproteobacterium also produces N-hexanoyl-HSL (C6-HSL) and N-octanoyl-HSL (C8-HSL) via Msal. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：561 / 567

页数：7