Pregnancy induced hypertension and polymorphism of the angiotensin converting enzyme

被引：0
|
作者：
Seremak-Mrozikiewicz, A [1 ]
Drews, K [1 ]
Slomko, Z [1 ]
Mrozikiewicz, A [1 ]
机构：
[1] Karol Marcinkowski Univ Med Sci, Dept Perinatol & Gynaecol, Div Perinatol, Poznan, Poland
来源：
4TH WORLD CONGRESS OF PERINATAL MEDICINE | 1999年
关键词：
D O I：
暂无
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
The insertion/deletion (I/D) polymorphism of angiotensin converting enzyme (ACE) was suggested to play an important role in aetiology of idiopathic hypertension. We have tested by polymerase chain reaction (PCR) assay this polymorphism in 58 pregnant women with PM and in 50 healthy pregnant women. We have amplified genomic DNA excteracted by phenol-chloroform method from blood leucocytes. We have detected overrepresentation of the I allele in the PIH group (47.4% and 41.0% in PM and controls, respectively). Genotype frequency in control group uas in agreement with expected values. according to Hardy Weinberg law. but in the PM group the obtained values were different from expected. This observation confirmed the possible role of I allele in aetiology of PIH.
引用
收藏
页码：99 / 101
页数：3
相关论文
共 50 条
  • [1] Association of angiotensin-converting enzyme gene polymorphism with pregnancy-induced hypertension
    Kaur, R
    Jain, V
    Khuller, M
    Gupta, I
    Sherawat, BS
    [J]. ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 2005, 84 (10) : 929 - 933
  • [2] ANGIOTENSIN-CONVERTING ENZYME IN PREGNANCY-INDUCED HYPERTENSION
    OATS, JN
    LONG, PA
    ANDERSEN, HM
    BEATON, LA
    [J]. CLINICAL AND EXPERIMENTAL HYPERTENSION PART B-HYPERTENSION IN PREGNANCY, 1982, 1 (2-3): : 231 - 231
  • [3] ANGIOTENSIN CONVERTING ENZYME AND THE PREGNANCY INDUCED HYPERTENSION-PRE-ECLAMPSIA SYNDROME
    GOLDKRAND, J
    FUENTES, A
    VANDERZEE, H
    [J]. CLINICAL AND EXPERIMENTAL HYPERTENSION PART B-HYPERTENSION IN PREGNANCY, 1987, 6 (01): : 69 - 69
  • [4] Angiotensin-converting enzyme gene polymorphism in systemic hypertension
    Abbud, ZA
    Wilson, AC
    Cosgrove, NM
    Kostis, JB
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 1998, 81 (02): : 244 - 246
  • [5] Angiotensin converting enzyme gene polymorphism in malignant hypertension.
    Stefansson, B
    Herlitz, H
    Ricksten, A
    Rymo, L
    Aurell, M
    [J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 1997, 8 : A1417 - A1417
  • [6] Microalbuminuria, hypertension and angiotensin converting enzyme gene polymorphism in IDDM
    Ciechanowicz, A
    Mamos, E
    Ryszkiewicz, D
    Naruszewicz, M
    Czekalski, S
    [J]. DIABETOLOGIA, 1997, 40 : 2051 - 2051
  • [7] ANGIOTENSIN-CONVERTING ENZYME POLYMORPHISM AND ESSENTIAL-HYPERTENSION
    MORISE, T
    TAKEUCHI, Y
    TAKEDA, R
    [J]. LANCET, 1994, 343 (8889): : 125 - 125
  • [8] THE RELATION OF ANGIOTENSIN-CONVERTING ENZYME TO THE PREGNANCY-INDUCED HYPERTENSION PREECLAMPSIA SYNDROME
    GOLDKRAND, JW
    FUENTES, AM
    [J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1986, 154 (04) : 792 - 800
  • [9] SERUM ANGIOTENSIN-CONVERTING ENZYME-ACTIVITY IN PREGNANCY-INDUCED HYPERTENSION
    LI, J
    HU, HY
    ZHAO, YN
    [J]. GYNECOLOGIC AND OBSTETRIC INVESTIGATION, 1992, 33 (03) : 138 - 141
  • [10] Insertion/deletion polymorphism of the angiotensin-converting enzyme gene and hypertension
    Liyou, N
    Simons, L
    Johnson, A
    [J]. CIRCULATION, 1999, 100 (17) : E85 - E85
12345