The Regulatory Role of Ferroptosis in Bone Homeostasis

被引：14
|
作者：
Xiong, Yuan [1 ,2 ]
Chen, Lang [1 ,2 ]
Lin, Ze [1 ,2 ]
Hu, Yiqiang [1 ,2 ]
Panayi, Adriana C. [3 ]
Zhou, Wu [1 ,2 ]
Sun, Yun [4 ]
Cao, Faqi [1 ,2 ]
Liu, Guodong [5 ]
Dai, Guangdong [6 ]
Mi, Bobin [1 ,2 ]
Liu, Guohui [1 ,2 ]
机构：
[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Orthopaed, Wuhan 430022, Peoples R China
[2] Hubei Prov Key Lab Oral & Maxillofacial Dev & Rege, Wuhan 430022, Peoples R China
[3] Harvard Med Sch, Brigham & Womens Hosp, Dept Plast Surg, Boston, MA 02152 USA
[4] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Neurosurg, Wuhan 430022, Peoples R China
[5] Army Med Univ, Daping Hosp, Med Ctr Trauma & War Injuries, Chongqing 400042, Peoples R China
[6] Southern Med Univ, Pingshan Dist Peoples Hosp Shenzhen, Pingshan Gen Hosp, Shenzhen 518118, Guangdong, Peoples R China
来源：
STEM CELLS INTERNATIONAL | 2022年 / 2022卷
基金：
中国国家自然科学基金;
关键词：
FERRITINOPHAGY; APOPTOSIS;
D O I：
10.1155/2022/3568597
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Ferroptosis is an iron-dependent form of programmed cell death and an important type of biological catabolism. Through the action of divalent iron or ester oxygenase, ferroptosis can induce lipid peroxidation and cell death, regulating a variety of physiological processes. The role of ferroptosis in the modulation of bone homeostasis is a significant topic of interest. Herein, we review and discuss recent studies exploring the mechanisms and functions of ferroptosis in different bone-related cells, including mesenchymal stem cells, osteoblasts, osteoclasts, and osteocytes. The association between ferroptosis and disorders of bone homeostasis is also explored in this review. Overall, we aim to provide a detailed overview of ferroptosis, summarizing recent understanding on its role in regulation of bone physiology and bone disease pathogenesis.
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页数：9
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