A multiscale modeling framework for studying the mechanobiology of sarcopenic obesity

被引:14
|
作者
Shoham, Naama [1 ]
Levy, Ayelet [1 ]
Shabshin, Nogah [2 ,3 ]
Benayahu, Dafna [4 ]
Gefen, Amit [1 ]
机构
[1] Tel Aviv Univ, Dept Biomed Engn, Fac Engn, IL-69978 Tel Aviv, Israel
[2] Haemek Med Ctr, Dept Radiol, Afula, Israel
[3] Hosp Univ Penn, Dept Radiol, 3400 Spruce St, Philadelphia, PA 19104 USA
[4] Tel Aviv Univ, Sackler Sch Med, Dept Cell & Dev Biol, Tel Aviv, Israel
基金
以色列科学基金会;
关键词
Adipose tissue; Adipogenesis; Mechanotransduction; Finite element model; INTERMUSCULAR ADIPOSE-TISSUE; SPINAL-CORD-INJURY; INTRAMUSCULAR FAT; INHIBITS ADIPOGENESIS; INSULIN-RESISTANCE; PHYSICAL-ACTIVITY; INDEPENDENT ASSOCIATIONS; CELL-PROLIFERATION; DOWN-REGULATION; WEIGHT-BEARING;
D O I
10.1007/s10237-016-0816-z
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
An inactive sedentary lifestyle is a common risk factor contributing to sarcopenic obesity. At the cell scale, sustained mechanical deformations of the plasma membrane (PM) in adipocytes, characterizing chronic static loading in weight-bearing tissues during prolonged sitting or lying, were found to promote adipogenesis. Taking a mechanobiological perspective, we correlated here the macroscale mechanical deformations of weight-bearing adipose tissues (subcutaneous and intramuscular) with mechanical strains developing in the PMs of differentiating adipocytes. An innovative multiscale modeling framework for adipose tissues was developed for this purpose, where the buttocks, adipose tissues, adipocytes and the subcellular components: intracytoplasmic nucleus and lipid droplets as well as the PMs of the cells, were all represented. We found that a positive feedback loop very likely exists and is involved in the onset and progression of sarcopenic obesity, as follows. Adipogenesis in statically deformed adipocytes results in gaining more macroscopic subcutaneous and intramuscular fat mass, which then increases fat deformations macroscopically and microscopically, and hence triggers additional adipogenesis, and so on. Our present study is highly relevant in research of sarcopenic obesity and other adipose-related diseases such as diabetes, since mechanical distortion of adipocytes promotes adipogenesis and fat gain at the different dimensional scales.
引用
收藏
页码:275 / 295
页数:21
相关论文
共 50 条
  • [1] A multiscale modeling framework for studying the mechanobiology of sarcopenic obesity
    Naama Shoham
    Ayelet Levy
    Nogah Shabshin
    Dafna Benayahu
    Amit Gefen
    [J]. Biomechanics and Modeling in Mechanobiology, 2017, 16 : 275 - 295
  • [2] Multiscale mechanobiology modeling for surgery assessment
    M. Garbey
    B. L. Bass
    S. Berceli
    [J]. Acta Mechanica Sinica, 2012, 28 (04) : 1186 - 1202
  • [3] Multiscale modeling of bone tissue mechanobiology
    Garcia-Aznar, Jose Manuel
    Nasello, Gabriele
    Hervas-Raluy, Silvia
    Perez, Maria Angeles
    Gomez-Benito, Maria Jose
    [J]. BONE, 2021, 151
  • [4] Multiscale mechanobiology modeling for surgery assessment
    Garbey, M.
    Bass, B. L.
    Berceli, S.
    [J]. ACTA MECHANICA SINICA, 2012, 28 (04) : 1186 - 1202
  • [5] Multiscale mechanobiology modeling for surgery assessment
    M. Garbey
    B. L. Bass
    S. Berceli
    [J]. Acta Mechanica Sinica, 2012, 28 : 1186 - 1202
  • [6] Multiscale modeling of growth plate cartilage mechanobiology
    Gao, Jie
    Williams, John L.
    Roan, Esra
    [J]. BIOMECHANICS AND MODELING IN MECHANOBIOLOGY, 2017, 16 (02) : 667 - 679
  • [7] Multiscale modeling of growth plate cartilage mechanobiology
    Jie Gao
    John L. Williams
    Esra Roan
    [J]. Biomechanics and Modeling in Mechanobiology, 2017, 16 : 667 - 679
  • [8] On modeling the multiscale mechanobiology of soft tissues: Challenges and progress
    Guo, Yifan
    Mofrad, Mohammad R. K.
    Tepole, Adrian Buganza
    [J]. BIOPHYSICS REVIEWS, 2022, 3 (03):
  • [9] Sarcopenic obesity
    Stergios A. Polyzos
    Andrew N. Margioris
    [J]. Hormones, 2018, 17 : 321 - 331
  • [10] Sarcopenic osteoporosis, sarcopenic obesity, and sarcopenic osteoporotic obesity in the Camargo cohort (Cantabria, Spain)
    Hernandez-Martinez, Paula
    Olmos, Jose M.
    Llorca, Javier
    Hernandez, Jose L.
    Gonzalez-Macias, Jesus
    [J]. ARCHIVES OF OSTEOPOROSIS, 2022, 17 (01)