Glycosamino acids: New building blocks for combinatorial synthesis

被引:138
|
作者
McDevitt, JP [1 ]
Lansbury, PT [1 ]
机构
[1] MIT,DEPT CHEM,CAMBRIDGE,MA 02139
关键词
D O I
10.1021/ja9525622
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
In order to produce inexpensive, chemically diverse carbohydrate building blocks more amenable for use in combinatorial organic synthesis, amine and carboxylic acid functional groups were incorporated into several monosaccharides. A series of 12 new glycosamino acids was prepared from commercially available starting materials. Conventional peptide synthesis solution coupling techniques were used to ligate glycosamino acids, producing oligomeric ''glycotides''. Finally, a library of glycotides was produced by coupling of a glycosamino acid mixture to a rigid template.
引用
收藏
页码:3818 / 3828
页数:11
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